Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study

Method of conception does not affect fetal or maternal outcomes in SARS-CoV-2 infected women, except for preeclampsia. High rate of operative delivery in SARSCoV-2 infected women, especially in in vitro fertilization pregnancies.

VOLUME 116, ISSUE 3, P731-740


Virginia Engels Calvo, Ph.D., Sara Cruz Melguizo, Ph.D., Alejandra Abascal-Saiz, Ph.D., Laura Forcén Acebal, M.D., Amalia Sánchez-Migallón, M.D., Pilar Pintado Recarte, Ph.D., Celia Cuenca Marín, M.D., Beatriz Marcos Puig, Ph.D., Pablo G. Del Barrio Fernández, Ph.D., Olga Nieto Velasco, Ph.D., María Luisa de la Cruz Conty, Ph.D., Oscar Martínez-Perez, Ph.D.  on behalf of theSpanish Obstetric Emergency Group



To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes).


Multicenter, prospective, observational study.


78 centers participating in the Spanish COVID19 Registry.


1,347 pregnant women with SARS-CoV-2 positive results registered consecutively between February 26 and November 5, 2020.


The patients’ information was collected from their medical records, and multivariable regression analyses were performed, controlling for maternal age and the clinical presentation of the infection.

Main Outcome Measure(s)

Obstetrics and neonatal outcomes, pregnancy comorbidities, intensive care unit admission, mechanical ventilation need, and medical conditions.


The IVF group included 74 (5.5%) women whereas the spontaneous pregnancy group included 1,275 (94.5%) women. The operative delivery rate was high in all patients, especially in the IVF group, where cesarean section became the most frequent method of delivery (55.4%, compared with 26.1% of the spontaneous pregnancy group). The reason for cesarean section was induction failure in 56.1% of the IVF patients. IVF women had more gestational hypertensive disorders (16.2% vs. 4.5% among spontaneous pregnancy women, adjusted odds ratio [aOR] 5.31, 95% confidence interval [CI] 2.45–10.93) irrespective of oocyte origin. The higher rate of intensive care unit admittance observed in the IVF group (8.1% vs. 2.4% in the spontaneous pregnancy group) was attributed to preeclampsia (aOR 11.82, 95% CI 5.25–25.87), not to the type of conception.


A high rate of operative delivery was observed in pregnant women infected with SARS-CoV-2, especially in those with IVF pregnancies; method of conception did not affect fetal or maternal outcomes, except for preeclampsia.

Clinical Trial Registration Number