November 2021: Fertilization rate as a novel indicator in ART results

Journal Club Global
November 2021: Fertilization rate as a novel indicator in ART results

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This Journal Club Global discusses a provocative article recently published in Fertility and Sterility, discussing the results of a multicenter retrospective cohort study with the objective to appraise the fertilization rate as a predictive factor for cumulative live birth rate (CLBR). The study is based on data from ten in vitro fertilization clinics collected and processed using a new software developed by the Italian National Registry designed to calculate cumulative results. In all, data from 7,968 couples undergoing 9,394 complete intracytoplasmic sperm injection cycles were taken into account.

The hosts facilitate the discussion following the presentation of the article’s results by Dr. Marine Poulain. The data indicate a positive association between fertilization rate and cumulative live birth rate (CLBR), suggesting the predictive relevance of this parameter and its adoption as a key performance indicator.

Additional discussants include experts in new ART developments including Dr. Catherine Racowsky, co-author of the article Dr. Andrea Borini, and Dr. Kathleen Hong.

Questions and issues addressed during the event include:

  • The place for fertilization rate
  • Its role as KPI in ART
  • Comparison to usable blastulation rate
  • Other markers of CLBR
  • Need to develop software capable of computing CLBR

Catherine Racowsky, Ph.D.
Andrea Borini, Ph.D.
Kathleen Hong, M.D.
Marine Poulain, Pharm, Ph.D.

Paul Pirtea, M.D.
Dominique De Ziegler, M.D.
Micah Hill, D.O.

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