July 2021

Volume 116, Issue 1

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From the Editor

The evolution of Fertility and Sterility
Kurt T. Barnhart
Vol 116 | No. 1 | July 2021 | Page 1

Views and Interviews: A Special Feature

In vitro fertilization and andrology laboratories in 2030
Carlos Simon, Alison Campbell, David K. Gardner, Marcos Meseguer, Kathleen A. Miller, Markus Montag, Gianpiero D. Palermo, Stephanie Cheung, Derek Keating, Philip Xie, Zev Rosenwaks, Laura Rienzi, Federica Innocenti, Danilo Cimadomo, Filippo Maria Ubaldi, Denny Sakkas, Michael J. Tucker, Liesl Nel-Themaat
Vol 116 | No. 1 | July 2021 | Pages 2-3 

In vitro fertilization and andrology laboratory in 2030: expert visions
Alison Campbell, David K. Gardner, Marcos Meseguer, Kathleen A. Miller, Markus Montag, Gianpiero D. Palermo, Stephanie Cheung, Derek Keating, Philip Xie, Zev Rosenwaks, Laura Rienzi, Federica Innocenti, Danilo Cimadomo, Filippo Maria Ubaldi, Denny Sakkas, Michael J. Tucker, Liesl Nel-Themaat, Carlos Simon
Vol 116 | No. 1 | July 2021 | Pages 4-12 

Consensus vision
Carlos Simon
Vol 116 | No. 1 | July 2021 | Pages 13-14

Fertile Battle

Coronavirus disease 2019 vaccination in women seeking pregnancy or in early pregnancy: What is there to debate?
Richard S. Legro
Vol 116 | No. 1 | July 2021 | Page 15

Should women undergoing in vitro fertilization treatment or who are in the first trimester of pregnancy be vaccinated immediately against COVID-19
Meredith L. Snook, Richard H. Beigi, Richard S. Legro, Catharine I. Paules
Vol 116 | No. 1 | July 2021 | Pages 16-24

Inklings

Human embryo genetic editing: hope or pipe dream?
Inmaculada de Melo-Martín, Zev Rosenwaks
Vol 116 | No. 1 | July 2021 | Pages 25-26

Seminal Contributions

Perinatal outcomes in singleton pregnancies after in vitro fertilization cycles over 24 years
Jaimin S. Shah, Denis A. Vaughan, Angela Leung, Ann Korkidakis, Francesc Figueras,  Desiree Garcia, Alan S. Penzias, Denny Sakkas
Vol 116 | No. 1 | July 2021 | Pages 27-35 

ASRM Pages

Evidence-based outcomes after oocyte cryopreservation for donor oocyte in vitro fertilization and planned oocyte cryopreservation: a guideline
The Practice Committee of the American Society for Reproductive Medicine
Vol 116 | No. 1 | July 2021 | Pages 36-47 

Disposition of unclaimed embryos: an Ethics Committee opinion
Ethics Committee of the American Society for Reproductive Medicine
Vol 116 | No. 1 | July 2021 | Pages 48-53 

Disparities in access to effective treatment for infertility in the United States: an Ethics Committee opinion
The Ethics Committee of the American Society for Reproductive Medicine
Vol 116 | No. 1 | July 2021 | Pages 54-63

Reflections

Singleton birth weight and premature birth after in vitro fertilization: Do we have evidence?
Mohamed Aboulghar, Mona Aboulghar
Vol 116 | No. 1 | July 2021 | Pages 64-65 

Intracytoplasmic sperm injection outcomes are comparable in ejaculated sperm but poor in testicular sperm. But why? An opportunity to further understand the AZFc region
Jason M. Scovell, Jesse Ory
Vol 116 | No. 1 | July 2021 | Page 66 

It is beneficial to support young, good prognosis patients, who strongly desire a biological child, through multiple cycles of treatment
Sofia Gameiro
Vol 116 | No. 1 | July 2021 | Pages 67-68

Sperm DNA fragmentation: a need to fully address the impact on fertility outcomes
Steven D. Spandorfer
Vol 116 | No. 1 | July 2021 | Pages 69-70 

Through thick and thin: time to stop worrying about endometrial thickness?
Natalie Stentz, Kate Devine
Vol 116 | No. 1 | July 2021 | Pages 71-72 

The quest for accurate diagnosis of early pregnancies: intrauterine genomic classifier
Peter Takacs
Vol 116 | No. 1 | July 2021 | Pages 73-74 

Growth differences after fresh and frozen embryo transfers: When do they begin?
Rachel Weinerman
Vol 116 | No. 1 | July 2021 | Pages 75-76 

Mosaic embryos: hiding in plain sight
Richard T. Scott Jr.
Vol 116 | No. 1 | July 2021 | Page 77

Endometrial receptivity: miRNAs signing in?
Elpida Fragouli, Anna Mantzouratou
Vol 116 | No. 1 | July 2021 | Pages 78-79 

Medical treatment with ulipristal acetate for uterine fibroids: Will it be resurrected?
James H. Liu
Vol 116 | No. 1 | July 2021 | Page 80

Breast cancer risk clouds fertility care
Gordon Wright Bates Jr.
Vol 116 | No. 1 | July 2021 | Pages 81-82 

Antimüllerian hormone–levels not written in stone
David H. Barad
Vol 116 | No. 1 | July 2021 | Pages 83-84 

Controlled ovarian hyperstimulation as a stress test for the thyroid
Tim I.M. Korevaar, Catherine E. de Keyser
Vol 116 | No. 1 | July 2021 | Pages 85-86

Adiposity in polycystic ovary syndrome: excess versus dysfunction
Ricardo Azziz
Vol 116 | No. 1 | July 2021 | Pages 87-88 

Adenomyosis: a riddle, wrapped in mystery, inside an enigma
Malcolm G. Munro
Vol 116 | No. 1 | July 2021 | Pages 89-90 

Fibroid stiffness: a cellular modulator of progesterone receptor signaling
Omid Khorram, Tsai-Der Chuang
Vol 116 | No. 1 | July 2021 | Page 91 

The new, new Vecchietti procedure: a study of disruptive engagement
Elizabeth A. Pritts
Vol 116 | No. 1 | July 2021 | Pages 92-93

Fertility and Sterility: 50 Years Ago Today

Exploring the mysteries of obstruction
Martin Kathrins
Vol 116 | No. 1 | July 2021 | Pages 94-95

Original Articles

Andrology

Poor intracytoplasmic sperm injection outcome in infertile males with azoospermia factor c microdeletions
Li Zhang, Jia-ming Mao, Ming Li, Ying Lian, Sheng-li Lin, Li-xue Chen, Li-ying Yan, Jie Qiao, Ping Liu
Vol 116 | No. 1 | July 2021 | Pages 96-104 

Assisted Reproduction

Possible association between in vitro fertilization technologies and offspring neoplasm
Maayan Hagbi Bal, Avi Harlev, Ruslan Sergienko, Eliahu Levitas, Iris Har-Vardi, Atif Zeadna, Aya Mark-Reich, Hadas Becker, Noa Ben-David, Lechaim Naggan, Tamar Wainstock
Vol 116 | No. 1 | July 2021 | Pages 105-113

Dropout rate and cumulative birth outcomes in couples undergoing in vitro fertilization within a funded and actively managed system of care in New Zealand
Laura M. Miller, Georgina Wallace, Mary A. Birdsall, Elizabeth R. Hammond, John C. Peek
Vol 116 | No. 1 | July 2021 | Pages 114-122

Oocyte ability to repair sperm DNA fragmentation: the impact of maternal age on intracytoplasmic sperm injection outcomes
Amanda Souza Setti, Daniela Paes de Almeida Ferreira Braga, Rodrigo Rosa Provenza, Assumpto Iaconelli Jr., Edson Borges Jr.
Vol 116 | No. 1 | July 2021 | Pages 123-129 

Endometrial thickness is not predictive for live birth after embryo transfer, even without a cutoff
Bahar Shakerian, Engin Turkgeldi, Sule Yildiz, Ipek Keles, Baris Ata
Vol 116 | No. 1 | July 2021 | Pages 130-137 

Early Pregnancy

An intrauterine genomic classifier reliably delineates the location of nonviable pregnancies
Jessica A. Lentscher, Zachary T. Colburn, Nicole Ortogero, Laurel Gillette,  George T. Leonard, Richard O. Burney, Gregory E. Chow
Vol 116 | No. 1 | July 2021 | Pages 138-146 

Greater fetal crown-rump length growth with the use of in vitro fertilization or intracytoplasmic sperm injection conceptions after thawed versus fresh blastocyst transfers: secondary analysis of a prospective cohort study
Paolo Ivo Cavoretto, Antonio Farina, Serena Girardelli, Gerarda Gaeta, Silvia Spinillo, Danila Morano, Silvia Amodeo, Alessandro Galdini, Paola Viganò, Massimo Candiani
Vol 116 | No. 1 | July 2021 | Pages 147-156

Genetics

Transcriptomic analysis of endometrial receptivity for a genomic diagnostics model of Chinese women
Wen-bi Zhang, Qing Li, Hu Liu, Wei-jian Chen, Chun-lei Zhang, He Li, Xiang Lu, Jun-ling Chen, Lu Li, Han Wu, Xiao-xi Sun
Vol 116 | No. 1 | July 2021 | Pages 157-164 

The morphokinetic signature of mosaic embryos: evidence in support of their own genetic identity
Ángel Martín, Lorena Rodrigo, Diana Beltrán, Marcos Meseguer, Carmen Rubio, Amparo Mercader, Maria Jose de los Santos
Vol 116 | No. 1 | July 2021 | Pages 165-173 

Preimplantation genetic testing results of blastocysts from 12 non-Robertsonian translocation carriers with chromosome fusion and comparison with Robertsonian translocation carriers
Pingyuan Xie, Yiqing Li, Dehua Cheng, Liang Hu, Yueqiu Tan, Keli Luo, Fei Gong, Guangxiu Lu, Ge Lin
Vol 116 | No. 1 | July 2021 | Pages 174-180

A novel platform for discovery of differentially expressed microRNAs in patients with repeated implantation failure
Ching Hung Chen, Farn Lu, Wen Jui Yang, Pok Eric Yang, Wei Ming Chen, Shih Ting Kang, Yu Shan Huang, Yi Chi Kao, Chi Ting Feng, Po Chang Chang, Tiffany Wang, Chi An Hsieh, Yu Chun Lin, Jack Yu Jen Huang, Lily Hui-Ching Wang
Vol 116 | No. 1 | July 2021 | Pages 181-188 

Gynecology

Ulipristal acetate compared with leuprorelin acetate for Japanese women with symptomatic uterine fibroids: a phase III randomized controlled trial
Yutaka Osuga, Yasuaki Nakano, Yuji Yamauchi, Masaya Takanashi
Vol 116 | No. 1 | July 2021 | Pages 189-197 

Infertility

Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis
Yusuf Beebeejaun, Abbeyrahmee Athithan, Timothy P. Copeland, Mohan S. Kamath, Ippokratis Sarris, Sesh K. Sunkara
Vol 116 | No. 1 | July 2021 | Pages 198-207 

Reproductive Endocrinology

Duration, recency, and type of hormonal contraceptive use and antimüllerian hormone levels
Lia A. Bernardi, Marissa Steinberg Weiss, Anne Waldo, Quaker Harmon, Mercedes R. Carnethon, Donna D. Baird, Lauren A. Wise, Erica E. Marsh
Vol 116 | No. 1 | July 2021 | Pages 208-217 

Thyroid function modifications in women undergoing controlled ovarian hyperstimulation for in vitro fertilization: a systematic review and meta-analysis
Andrea Busnelli, Federico Cirillo, Paolo Emanuele Levi-Setti
Vol 116 | No. 1 | July 2021 | Pages 218-231 

Accelerated subcutaneous abdominal stem cell adipogenesis predicts insulin sensitivity in normal-weight women with polycystic ovary syndrome
Daniel A. Dumesic, Ayli Tulberg, Karen L. Leung, Samantha C. Fisch, Tristan R. Grogan, David H. Abbott, Rajanigandha Naik, Gregorio D. Chazenbalk
Vol 116 | No. 1 | July 2021 | Pages 232-242 

Reproductive Science 

Adenomyosis is associated with specific proton nuclear magnetic resonance (1H-NMR) serum metabolic profiles
Mathilde Bourdon, Pietro Santulli, Fatiha Kateb, Khaled Pocate-Cheriet, Frederic Batteux, Chloé Maignien, Sandrine Chouzenoux, Corinne Bordonne,  Louis Marcellin, Gildas Bertho, Charles Chapron
Vol 116 | No. 1 | July 2021 | Pages 243-254 

Mechanical stiffness augments ligand-dependent progesterone receptor B activation via MEK 1/2 and Rho/ROCK–dependent signaling pathways in uterine fibroid cells
Christina N. Cordeiro Mitchell, Md Soriful Islam, Sadia Afrin, Joshua Brennan, Kevin J. Psoter, James H. Segars
Vol 116 | No. 1 | July 2021 | Pages 255-265 

Videos

Modified Vecchietti vaginoplasty using self-made single-port laparoscopy in Mayer-Rokitansky-Küster-Hauser syndrome
Xinyun Yang, Junxiao Liang, Wenjuan Li, Bingya Chen, Xiaoyan Sun, Zhenwei Xie
Vol 116 | No. 1 | July 2021 | Pages 266-268

Clinical use of indocyanine green during nerve-sparing surgery for deep endometriosis
Kiyoshi Kanno, Kiyoshi Aiko, Shiori Yanai, Mari Sawada, Shintaro Sakate, Masaaki Andou
Vol 116 | No. 1 | July 2021 | Pages 269-271 

4D ultrasound as a method to assess uterine peristalsis
Belén Moliner, Joaquin Llacer, Francisco Sellers, Juan Carlos Castillo, Ana Fuentes, Andrea Bernabeu, Rafael Bernabeu
Vol 116 | No. 1 | July 2021 | Pages 272-274 

Transvaginal ultrasound features of normal uterosacral ligaments
Luca Savelli, Marco Ambrosio, Paolo Salucci, Diego Raimondo, Alessandro Arena, Renato Seracchioli
Vol 116 | No. 1 | July 2021 | Pages 275-277

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.