Follicle-stimulating hormone receptor autoantibody associated primary ovarian insufficiency successfully treated with corticosteroids: a case report

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VOLUME 1, ISSUE 3, P206-208, DECEMBER 01, 2020

Authors:

Carrie Riestenberg, M.D., Susan Ahern, D.O., Mousa Shamonki, M.D.

Abstract:

Objective

To report a case of successful controlled ovarian stimulation (COH) for oocyte cryopreservation in a patient with autoimmune primary ovarian insufficiency (POI) and polyglandular autoimmune syndrome (PGAS) type 2.


Design

Case report.


Setting

Private in vitro fertilization clinic.


Patient(s)

25-Year-old woman, G0, with autoimmune POI and PGAS type 2.


Intervention(s)

Diagnosis of autoimmune interference with FSH signaling, with subsequent high-dose corticosteroid immune suppression and successful oocyte cryopreservation.


Main Outcomes Measure(s)

Successful stimulation with exogenous gonadotropins, oocyte retrieval, and cryopreservation.


Result(s)

Retrieval and cryopreservation of 36 metaphase-II (MII) oocytes.


Conclusion(s)

Scrutiny of POI cases will facilitate identification of a subset of patients in whom immune suppression with short-term, high-dose corticosteroids may enable successful COH.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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