Fibrosis as a molecular hallmark of endometriosis pathophysiology

Fibrosis as a molecular hallmark of endometriosis pathophysiology


Go to the profile of Pandiyan  Natarajan
about 1 month ago

Fibrosis is the consequence of Endometriosis and not the cause of Endometriosis.

Endometriosis remains a Gynecological enigma. Though Retrograde Menstruation remains the proximate cause, (1) and almost all menstruating women  do have Retrograde Menstruation, yet only a certain percentage of genetically prone and immunologically susceptible women develop Endometriosis. Many women with Endometriosis don’t develop any symptoms and it is often an incidental diagnosis at Laparoscopy or Laparotomy.

Much emphasis has been laid on Early diagnosis, though it is not clear what could be achieved by early diagnosis. (2) Pregnancy ameliorates the Condition and Menopause is the only known cure for the condition. The condition runs an unpredictable course and spontaneous remission is known.

We feel, based on extensive experience in this field that, Infertility leads to Endometriosis. Endometriosis with adhesions & anatomical distortion  further worsens Infertility. (3)


1.Etiology of Endometriosis- Simplified. 

Surya P, Pandiyan N.

2. Early Diagnosis of Endometriosis – Quo Vadis?
Pandiyan N, Surya P,  Shah Dupesh Khan , Radha Pandiyan

3. Infertility (Non Conception) with Regular Menstruation Predisposes to
Endometriosis – A Hypothesis
Pandiyan N, Surya P,  Radha Pandiyan

Professor Dr Pandiyan Natarajan,

Chief Consultant in Andrology and Reproductive Sciences,


Chettinad Super Speciality Hospital ( Retired )