Evaluation of human papilloma virus in semen as a risk factor for low sperm quality and poor in vitro fertilization outcomes: a systematic review and meta-analysis

The presence of human papilloma virus DNA in semen was found to be associated with reduced sperm parameters and increased miscarriage rates and should be further studied to evaluate the clinical significance.

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Volume 113, Issue 5, Pages 955–969.e4

Authors:

May Weinberg, B.Sc., Chen Sar-Shalom Nahshon, B.Sc., Ido Feferkorn, M.D., Jacob Bornstein, M.D., M.P.A.

Abstract:

Objective

To analyze the effect of human papilloma virus (HPV) sperm infection on sperm parameters and in vitro fertilization (IVF) outcomes.

Design

Systematic review and meta-analysis.

Setting

Not applicable.

Patients

Men with HPV sperm infection and couples undergoing IVF.

Interventions

Searches were conducted in the following databases: Medline(R), PubMed, Embase, Web of Science, Scopos, and the Cochrane Library. We included studies examining sperm parameters and IVF results in patients with and without HPV sperm infection.

Main Outcome Measures

Sperm analysis (concertation, count, volume, motility, morphology), according to the World Health Organization manual, pregnancy rate (PR), and miscarriage rate (MR).

Results

Sixteen studies were included in this meta-analysis. The presence of HPV had a significant association with impaired sperm parameters in terms of concentration (mean difference [MD] −4.48, 95% confidence interval [CI] − 6.12 to −2.83), motility (MD −11.71, 95% CI − 16.15 to −7.26), and morphology (MD −2.44, 95% CI − 4.08 to −0.79. A review of the literature regarding ART outcomes showed an association between HPV infection and decreased PR, and an even stronger association between HPV infection and increased MR.

Conclusion

Our meta-analysis shows a negative effect of HPV on sperm concentration, motility, and morphology. Further subgroup and categorical analysis confirmed the clinical significance of impaired sperm motility in HPV-infected sperm, although the sperm count and morphology must be carefully analyzed. The studies reviewed reported lower PR and increased MR in couples with HPV-infected sperm. As most studies had a moderate risk of bias, these observations warrant further large, well-designed studies before introducing clinical management recommendations.

PROSPERO Registration Number

CRD42019127419



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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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