Evaluating efficacy of intravenous carbetocin in reducing blood loss during abdominal myomectomy: a randomized controlled trial

Use of 100 mg carbetocin intravenously may reduce intraoperative blood loss and need for blood transfusion during abdominal myomectomy. Carbetocin is well tolerated with few side-effects.

VOLUME 115, ISSUE 3, P793-801, MARCH 01, 2021


Ayman Taher, M.D., Dalia Farouk, M.D., Mohamed Mahmoud Mohamed Kotb, M.D., Nevein Kamal Ghamry, M.D., Khaled Kholaif, M.D., Ahmed A. Mageed A. Allah, M.D., Ahmed Said Ali, M.B.B.Ch., Omneya M. Osman, M.D., Hala Nabil, M.D., Yomna Islam, M.D., Mohamed Sobhy Bakry, M.D., Bassem Aly Islam, M.D., Mahmoud Alalfy, M.D., Salma Ashraf Nassar, M.D., Almandouh H. Bosilah, M.D., Ashraf A. Ghanem, M.D., Nansy Mohamed Ali Rund, M.D., Rania Refaat, M.D., Hamada Ashry Abdel Wahed Ali, M.D., Ahmed Bakry, M.D., Ahmed S.A. Ashour, M.D., Mohamed Nabil, M.D., Sherif Sameh Zaki, M.D.



To evaluate the efficacy of carbetocin versus placebo in decreasing intraoperative blood loss and the need for blood transfusion during abdominal myomectomy.


Randomized, double-blind, placebo-controlled trial.


Tertiary university hospital from September 2019 to February 2020.


A total of 138 women with symptomatic leiomyoma who were candidates for abdominal myomectomy (n = 69 in each group).


We randomized the study participants in a 1:1 ratio to carbetocin and placebo groups. Intravenous 100 μg carbetocin or placebo was administered slowly after induction of anesthesia.

Main Outcome Measure(s)

Intraoperative blood loss, need for blood transfusion, postoperative hemoglobin, operative time, length of hospitalization, and drug side-effects.


The baseline characteristics were similar among all groups. Carbetocin had significantly lower intraoperative blood loss compared with placebo (mean difference 184 mL). Hemoglobin level 24 hours after surgery was significantly lower in the placebo group than in the carbetocin group (9.1 ± 0.8 vs. 10.3 ± 0.6 g/dL). Eight women in the carbetocin group needed blood transfusion compared with 17 in placebo group. Operative time, length of hospitalization, and side-effects were similar in both groups.


A single preoperative intravenous dose of 100 μg carbetocin is a simple, practical, and effective method of decreasing intraoperative blood loss and the need for blood transfusion during abdominal myomectomy, with tolerable, few, nonsignificant side-effects.

Clinical Trial Registration Number