Endometrium preparation and perinatal outcomes in women undergoing single-blastocyst transfer in frozen cycles

Hormone replacement cycles are associated with an increased risk of preterm delivery, cesarean delivery, low birth weight, macrosomia, premature rupture of membrane, and hypertensive disorders of pregnancy.

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VOLUME 115, ISSUE 6, P1487-1494

Authors:

Kai-Lun Hu, M.D., Dan Zhang, M.D., Ph.D., Rong Li, M.D., Ph.D. 

Abstract:

Objective

To investigate the association of endometrium preparation with perinatal outcomes.


Design

Retrospective cohort study.


Setting

University-affiliated fertility center.


Patient(s)

Twenty-one thousand six hundred and forty-eight women who underwent frozen single-blastocyst transfer from January 2013 to March 2019.


Intervention(s)

None.


Main Outcome Measure(s)

Cesarean delivery, preterm delivery (PTD), vaginal PTD, very preterm delivery (VPTD), postterm delivery, low birth weight (LBW), macrosomia, small for gestational age (SGA), large for gestational age (LGA), hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), premature rupture of membrane (PROM), placenta previa, and congenital abnormality.


Result(s)

Compared with natural cycles, hormone replacement cycles were associated with an increased risk of PTD, VPTD, cesarean delivery, macrosomia, PROM, and HDP. There was a trend toward an increased risk of vaginal PTD and LGA in hormone replacement cycles. Stimulated cycles were associated with an increased risk of postterm delivery and GDM. There was no statistically significant difference in the rate of SGA, placenta previa, or congenital abnormality among the three endometrium preparation methods.


Conclusion(s)

Hormone replacement cycles are associated with an increased risk of PTD, VPTD, cesarean delivery, LBW, macrosomia, PROM, and HDP. Stimulated cycles are associated with an increased risk of postterm delivery and GDM.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.