Effect of body mass index on intrauterine insemination cycle success

Obesity is associated with a higher risk of biochemical pregnancy but no difference in live birth rates after intrauterine insemination compared with women of normal body mass index.

VOLUME 115, ISSUE 1, P221-228


Rachel M. Whynott, M.D., Karen M. Summers, M.P.H., Bradley J. Van Voorhis, M.D., Rachel B. Mejia, D.O.



To determine whether body mass index (BMI) affects intrauterine insemination treatment success.


Retrospective cohort study.


Academic medical center.


A total of 3,217 intrauterine insemination treatment cycles in 1,306 patients.



Main Outcome Measure(s)

Primary outcome was live birth rate stratified by BMI. Secondary outcomes included rates of clinical pregnancy (defined as an intrauterine pregnancy with a heartbeat present on ultrasound), multiple gestation, biochemical pregnancy, missed abortion, ectopic, and spontaneous abortion.


Women with BMI 25 to 29.99 kg/m2 or ≥30 kg/m2 were equally likely to have a live birth as women of normal BMI. Women with BMI ≥30 kg/m2 did have a higher likelihood of biochemical pregnancy than women with normal BMI.


A BMI between 25 and 29.99 kg/m2 or ≥30 kg/m2 does not appear to have a negative effect on live birth after intrauterine insemination. Obesity may be associated with a higher risk of biochemical pregnancy after intrauterine insemination.