Do we need to separate initiation and growth to understand endometriosis?


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VOLUME 114, ISSUE 4, P766-767


Philippe R. Koninckx, M.D., Ph.D., Dan C. Martin, M.D., Jacques Donnez, M.D., Ph.D. 


Reflections on "Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis" by Zhan et al.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. 


Go to the profile of Hazout Andre
over 1 year ago

I agree with everything that is mentioned in this reflection and I would like to stress the high probability of the epigenetic origin of endometriosis. The presence of endometriosis in the male and the fetus suggests that the epigenetic origin is well established, on the basis of numerous studies determining many candidate genes (CALD1, FN1, FASN, IL6, etc ...) The methylation status of these genes seems to be decisive for understanding the prognosis and the evolution of the endometriotic disease. These genes are accessible by the study of free DNA fragments in circulating blood and their methylation status, studied by our team (patent pending) has enabled us to establish not only early diagnosis but also a prognosis. as to the scalability of endometriosis foci. A therapeutic argument is at the end of validation and the results on pain and comfort of life seem promising