December 2020: Live from India: Adjuvants in IVF and IVF Add-Ons for the Endometrium
Journal Club Global
Many adjuvants have been utilized by IVF centers to improve their success rates. No high-quality randomized trial has been conducted to evaluate the effectiveness and safety of these interventions in clinical settings. Proponents of using these technologies believe that couples are losing time until evidence is collected. While opponents object to their indiscriminate use, and they believe it is unethical to use them until evidence is available. Hence, there is an urgent need to develop robust well-designed RCTs to address all aspects of these interventions.
Hosts, Dr. Duru Shah, Dr. Kurt Barnhart, and Fellow Vishesha Yadav, will facilitate discussion of the value of ad-on treatments for IVF with authors, Dr. Mohan Kamath, Dr. Mariano Mascarenhas, and Dr. Sesh Sunkara, with input from experts, Dr. David Adamson and Professor Gamal Serour.
To discuss the use of various adjuvants, various issues will be addressed during the discussion:
- Why, when and how are different “add-ons” commonly used during the pre-IVF, stimulation, and luteal phase of an IVF cycle?
- What is the available evidence?
- How do we determine the right doses and could higher doses harm the embryo/developing fetus?
- Are “add-ons” customized for every patient or are they used indiscriminately?
- Is it ethical to use them without the availability of quality scientific evidence?
- Is it necessary to counsel the couple prior to their use and obtain consent for use?
Dr. Mohan Kamath, Dr. Mariano Mascarenhas, and Dr. Sesh Sunkara
Papers for Discussion
Clinical Adjuvants in IVF: A Growing List, Mohan Kamath, Mariano Mascarenhas, Sebastian Franik, Emily Liu and Sesh Kamal Sunkara, and IVF Add -Ons for the Endometrium: It Doesn’t Add Up, Sarah Lensen, Norman Shreeve, Kurt T. Barnhart, Ahmed Gibreel and Ernest Hung Yu Ng
Dr. G. David Adamson is a reproductive endocrinologist and surgeon, Clinical Professor ACF at Stanford University and Past President of the American Society for Reproductive Medicine (ASRM), Society for Assisted Reproductive Technology (SART) and numerous other societies. He has more than 300 peer-reviewed publications, has lectured extensively on ART, infertility and endometriosis, and has received numerous professional awards for his contributions to reproductive medicine.
Dr. Gamal Serour is Professor of Obstetrics and Gynecology and Director, International Islamic Center For Population Studies and Research (IICPSR) and the Egyptian IVR & ET Center. He is President of the African Federation of Fertility Societies (AFFS) and the Egyptian Fertility and Sterility Society (EFSS), as well as Past President of the International Federation of Gynecology and Obstetrics (FIGO).
Dr. Duru Shah is a Fertility specialist and Reproductive surgeon. She is currently the Director of Gynaecworld, the Center for Women’s Health and Fertility, the Founder President of the PCOS Society of India and the Immediate Past Chair of the ISIG at ASRM. She has been the Past President of the Indian Society of Assisted Reproduction, the Past Chair of the Indian College of Obstetrics and Gynecology and many other Organizations. She has lectured extensively both nationally and internationally, and has been conferred the Honory Fellowship of the Royal College of Obstetricians and Gynaecologists.
Dr. Vishesha Yadav is a Fellow with Gynaecworld, India. She is a gynecologist and IVF specialist focusing on infertility evaluation, laparoscopic surgery, in vitro fertilization (IVF), gynecologic and high-risk pregnancy care, as well as normal and cesarean delivery procedures.
Dr. Kurt Barnhart is Associate Chief, Penn Fertility Care, Director, Women's Health Clinical Research Center, Vice Chair for Clinical Research, William Shippen, Jr. Professor of Obstetrics and Gynecology, and Professor of Epidemiology in Biostatistics and Epidemiology at the University of Pennsylvania. He serves as New Media Editor of Fertility and Sterility.