Coronavirus disease 2019 vaccination in women seeking pregnancy or in early pregnancy: What is there to debate?

Fertile Battle

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VOLUME 116, ISSUE 1, P15


Richard S. Legro, M.D.


This issue’s Fertile Battle debates what for several clinicians is a nonissue, that is, coronavirus disease 2019 (COVID-19) vaccination in women seeking pregnancy or in early pregnancy. The overwhelming consensus supported by the recommendations from the Centers for Disease Control and Prevention and our governing professional societies is that it should be offered to most patients in these categories. Such recommendations, if incorporated into guidelines, may have a mixed risk–benefit ratio, especially if they are based on limited or misinterpreted clinical trial information (1). Moreover, once promulgated, they are difficult, in the absence of data, to modify. Questioning the maternal COVID-19 vaccination recommendations, given the well-documented risks to women who are pregnant by COVID-19 infection, can be considered a threat to women’s health and perhaps also a threat to science given the extensive research that has been carried out into the development and testing of these vaccines.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.