Coenzyme Q10 supplementation of human oocyte in vitro maturation reduces postmeiotic aneuploidies

Coenzyme Q10 supplementation during oocyte in vitro maturation increased oocyte maturation rates and reduced postmeiotic aneuploidies for older women.

Like Comment
Related Content

VOLUME 114, ISSUE 2, P331-337


Long Ma, M.S., Lingbo Cai, Ph.D., Mengting Hu, M.S., Jing Wang, M.D., Ph.D., Jiazi Xie, M.S., Yan Xing, M.D., Ph.D., Jiandong Shen, M.D., Ph.D., Yugui Cui, Ph.D., X. Johné Liu, Ph.D., Jiayin Liu, M.D., Ph.D.



To evaluate the effect of coenzyme Q10 (CoQ10) supplementation on oocyte maturation rates and postmeiotic aneuploidy rates during in vitro maturation (IVM) of human oocytes.


Clinical laboratory observation.


Hospital and university laboratories.


Forty-five patients aged ≥38 years and 18 patients aged ≤30 years undergoing in vitro fertilization.


The germinal vesicle–stage oocytes and associated cumulus cells were cultured in IVM media for 24–48 hours with or without 50 μmol/L CoQ10. Oocyte maturation rates were determined based on the presence or absence of the first polar body. Postmeiotic aneuploidies were determined using next-generation sequencing analyses of biopsied polar bodies.

Main Outcome Measure(s)

Oocyte maturation rates, postmeiotic oocyte aneuploidy rates, and chromosome aneuploidy frequencies.


In women aged 38–46 years, 50 μmol/L CoQ10 significantly increased oocyte maturation rates (82.6% vs. 63.0%; P=.035), reduced oocyte aneuploidy rates (36.8% vs. 65.5%; P=.020), and reduced chromosome aneuploidy frequencies (4.1% vs. 7.0%; P=.012. In women aged ≤30 years, we failed to demonstrate an effect of CoQ10 on oocyte maturation rates or postmeiotic aneuploidies.


CoQ10 supplementation during IVM increased oocyte maturation rates and reduced postmeiotic aneuploidies for older women.

Read the full text here. 

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.