Chemotherapy with alkylating agents: is follicle activation the only mechanism responsible for the loss of primordial follicles?

Reflections
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Chemotherapy with alkylating agents: is follicle activation the only mechanism responsible for the loss of primordial follicles?
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Chemotherapy with alkylating agents: Is follicle activation the only mechanism responsible for the loss of primordial follicles?

The detrimental effects of chemotherapeutic drugs on female reproduction have been known now for half a century. Still, understanding how chemotherapy affects gonadal function is a pressing issue. Indeed, one particular alkylating agent, cyclophosphamide (Cy), which induces DNA crosslinking and ulti…

VOLUME 115, ISSUE 5, P1166-1167

Authors:

Marie-Madeleine Dolmans, M.D., Ph.D., Jacques Donnez, M.D., Ph.D.

Abstract:

Reflections on "Ovaries of patients recently treated with alkylating agent chemotherapy indicate the presence of acute follicle activation, elucidating its role among other proposed mechanisms of follicle loss" by Shai et al. 

Read the full text here. 

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Fertility and Sterility
Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. 

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