Body mass index is not associated with embryo ploidy in patients undergoing in vitro fertilization with preimplantation genetic testing

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Authors:

Yael R. Stovezky, B.A., Phillip A. Romanski, M.D., Pietro Bortoletto, M.D., Steven D. Spandorfer, M.D.

Abstract:

Objective

To assess the association between body mass index (BMI) and embryo aneuploidy and mosaicism in a cohort of patients undergoing in vitro fertilization (IVF) with trophectoderm biopsy for preimplantation genetic testing for aneuploidy (PGT-A) using next-generation sequencing technology.


Design

Retrospective cohort study.


Setting

Academic center.


Patients

Patients undergoing their first IVF cycle with trophectoderm biopsy and PGT-A at our center between January 1, 2017, and August 31, 2020. Patients classified as underweight on the basis of BMI (BMI <18.5 kg/m2) and patients who underwent fresh embryo transfers were excluded.


Intervention

None.


Main Outcome Measures

Number and proportion of aneuploid, mosaic, and euploid embryos.


Results

The patients were stratified according to the World Health Organization’s BMI classification: normal weight (18.5–24.9 kg/m2, n = 1,254), overweight (25–29.9 kg/m2, n = 351), and obese (≥30 kg/m2, n = 145). Age-adjusted regression models showed no relationship between BMI classification and the number or proportion of aneuploid embryos. There were no statistically significant associations between BMI classifications and the number or proportion of mosaic or euploid embryos. A subgroup analysis of patients classified into age groups of <35, 35–40, and >40 years similarly showed no relationships between BMI and embryo ploidy outcomes.


Conclusion

Body mass index was not associated with the number or proportion of aneuploid, mosaic, or euploid embryos in this large cohort of patients undergoing IVF with PGT-A, suggesting that the negative effect of excess weight on reproductive outcomes was independent of the ploidy status of the embryo cohort.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.