Body mass index is not associated with donor oocyte recipient success: an ideal study using a paired analysis of sibling-oocytes

Original Articles: In Vitro Fertilization

Volume 1, Issue 1, Pages 25–29


Robert Setton, M.D., Alice Chung, B.A., Lilli Zimmerman, M.D., Alexis Melnick, M.D., Zev Rosenwaks, M.D., Steven D. Spandorfer, M.D.



To determine whether a higher body mass index (BMI) adversely affects endometrial receptivity.


Retrospective cohort study.


Academic medical center.


All donor egg recipients (DERs) who received fresh sibling-oocytes (oocytes from a donor that were retrieved from a single controlled ovarian hyperstimulation [COH] cycle and split between two recipients) at our center over a 7-year period were included.


COH of a donor with fresh embryo transfer to recipients of differing BMI. The two recipients of the sibling-oocytes were paired and categorized based on BMI: group A (normal weight, BMI 18.5−24.9 kg/m2) and group B (overweight/obese, BMI >25.0 kg/m2).

Main Outcome Measure(s)

The primary outcome was implantation rate. Secondary outcomes were positive pregnancy rate and live birth rate.


A total of 408 patients had received oocytes from a split donor oocyte cycle. There were 71 pairs of patients (142 recipients) that had discrepant BMI categories and were analyzed. Implantation rates were similar for the two groups (54.5%±5.3% vs. 56.3%±4.8% for group A and B, respectively, P=0.72). The positive pregnancy rate (77.5% vs. 80.3%, P=0.28) and live birth rate (54.9% vs. 60.6%, P=0.33) for groups A and B were also found to be similar.


In this idealized model that controls to the greatest degree possible for factors that would impact implantation, we found that a higher BMI did not reduce implantation, positive pregnancy, or delivery rates. These findings suggest that a higher BMI does not adversely affect uterine receptivity.

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