Body mass index is not associated with donor oocyte recipient success: an ideal study using a paired analysis of sibling-oocytes

Original Articles: In Vitro Fertilization

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Volume 1, Issue 1, Pages 25–29

Authors:

Robert Setton, M.D., Alice Chung, B.A., Lilli Zimmerman, M.D., Alexis Melnick, M.D., Zev Rosenwaks, M.D., Steven D. Spandorfer, M.D.

Abstract:

Objective

To determine whether a higher body mass index (BMI) adversely affects endometrial receptivity.

Design

Retrospective cohort study.

Setting

Academic medical center.

Patient(s)

All donor egg recipients (DERs) who received fresh sibling-oocytes (oocytes from a donor that were retrieved from a single controlled ovarian hyperstimulation [COH] cycle and split between two recipients) at our center over a 7-year period were included.

Intervention(s)

COH of a donor with fresh embryo transfer to recipients of differing BMI. The two recipients of the sibling-oocytes were paired and categorized based on BMI: group A (normal weight, BMI 18.5−24.9 kg/m2) and group B (overweight/obese, BMI >25.0 kg/m2).

Main Outcome Measure(s)

The primary outcome was implantation rate. Secondary outcomes were positive pregnancy rate and live birth rate.

Result(s)

A total of 408 patients had received oocytes from a split donor oocyte cycle. There were 71 pairs of patients (142 recipients) that had discrepant BMI categories and were analyzed. Implantation rates were similar for the two groups (54.5%±5.3% vs. 56.3%±4.8% for group A and B, respectively, P=0.72). The positive pregnancy rate (77.5% vs. 80.3%, P=0.28) and live birth rate (54.9% vs. 60.6%, P=0.33) for groups A and B were also found to be similar.

Conclusion(s)

In this idealized model that controls to the greatest degree possible for factors that would impact implantation, we found that a higher BMI did not reduce implantation, positive pregnancy, or delivery rates. These findings suggest that a higher BMI does not adversely affect uterine receptivity.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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