Automated identification of rare sperm becomes possible: Is sperm selection the next frontier in male infertility?

Reflections
Automated identification of rare sperm becomes possible: Is sperm selection the next frontier in male infertility?

VOLUME 118, ISSUE 1, P100

Authors:

Lewin Staine, M.D., Jaden R. Kohn, M.D., M.P.H., Taylor P. Kohn, M.D., M.Phil.

Abstract:

Reflections on "Automated rare sperm identification from low-magnification microscopy images of dissociated microsurgical testicular sperm extraction samples using deep learning" by Lee et al.

Read the full text here. 

Comments

Go to the profile of Pandiyan  Natarajan
about 2 months ago

Spermatozoa selection - The Road to Nowhere

I read with considerable interest the Reflections on,” Automated identification of spermatozoon and spermatozoa selection.”  I write this note based on my extensive experience with CASA in the earlier yers of CASA. Automated identification of the wrong structure as Spermatozoon or failure to identify the spermatozoon by the automated system is still a real possibility with attendant risks of inability to attempt ICSI. I am not sure as to how many Embryologists would be happy to let the system decide on the presence or absence of spermatozoa. Most, I feel would prefer to check the sample personally than let the system make the decision for them.

Spermatozoa Function Tests so far have been, “ Road to Nowhere.” All the Spermatozoa Function tests proposed or practiced so far have failed to translate their usefulness to clinical practice including the currently popular DNA Fragmentation Tests.(1). 

Raman Spectroscopy is unlikely to give any useful information on the DNA content or DNA Fragmentation of Spermatozoa. It gives information on the Chemical structure. The premise appears wrong based on the physical principles of Raman Effect. The other Function Test alluded in the article like Embryo selection methods also remain inconclusive.

1. A Perspective on Sperm DNA Fragmentation.

Natarajan Pandiyan, Radha Pandiyan, D. Ramesh Raja

https://tau.amegroups.com/article/view/14381/17136

Professor Dr Pandiyan Natarajan.

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY.

Chettinad Super Speciality Hospital ( Retired )

Professor Emeritus.

The Tamil Nadu Dr MGR Medical University.