April 2021

Volume 115, Issue 4

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Views and Reviews

The COVID-19 pandemic and reproductive health
Richard S. Legro
Vol 115 | No. 4 | April 2021 | Pages 811-812

The impact of SARS-CoV-2 and COVID-19 on male reproduction and men’s health
Darshan P. Patel, Nahid Punjani, Jingtao Guo, Joseph P. Alukal, Philip S. Li, James M. Hotaling
Vol 115 | No. 4 | April 2021 | Pages 813-823

The effects of COVID-19 on pregnancy and implications for reproductive medicine
Naima T. Joseph, Sonja A. Rasmussen, Denise J. Jamieson
Vol 115 | No. 4 | April 2021 | Pages 824-830 

Infection precautions for severe acute respiratory syndrome coronavirus 2 in assisted reproduction centers: dodging an invisible bullet
Amy E.T. Sparks, Jessica D. Kresowik
Vol 115 | No. 4 | April 2021 | Pages 831-839

Fertile Battle 

Noninvasive preimplantation genetic testing for aneuploidy in spent blastocyst media will substitute for trophectoderm biopsy
Carlos Simon
Vol 115 | No. 4 | April 2021 | Page 840

Noninvasive preimplantation genetic testing for aneuploidy in spent culture medium as a substitute for trophectoderm biopsy
Carmen Rubio, Catherine Racowsky, David H. Barad, Richard T. Scott Jr., Carlos Simon
Vol 115 | No. 4 | April 2021 | Pages 841-849

Inklings

Darwin meets Mendel in the reproductive medicine field: Homo sapiens 2.0 is inevitable
Jeanne E. O’Brien, Eli Y. Adashi, Carlos Simon
Vol 115 | No. 4 | April 2021 | Pages 850-851

Seminal Contributions

Simulation training for embryo transfer: findings from the American Society for Reproductive Medicine Embryo Transfer Certificate Course
Sarah D. Ramaiah, Keith A. Ray, Richard H. Reindollar
Vol 115 | No. 4 | April 2021 | Pages 852-859

ASRM Pages

Human immunodeficiency virus and infertility treatment: an Ethics Committee opinion
Ethics Committee of the American Society for Reproductive Medicine
Vol 115 | No. 4 | April 2021 | Pages 860-869

Development of an emergency plan for in vitro fertilization programs: a committee opinion
Practice Committees of the American Society for Reproductive Medicine, the Society for Assisted Reproductive Technology, and the Society of Reproductive Biologists and Technologists
Vol 115 | No. 4 | April 2021 | Pages 870-873

Access to fertility services by transgender and nonbinary persons: an Ethics Committee opinion
Ethics Committee of the American Society for Reproductive Medicine
Vol 115 | No. 4 | April 2021 | Pages 874-878

Reflections

Validation of a highly realistic embryo transfer simulator and trainer
James Segars, Michael A. Thomas
Vol 115 | No. 4 | April 2021 | Pages 879-880

The importance of microdissection testicular sperm extraction intervention after prior failed nonobstructive azoospermia treatment
Peter N. Schlegel
Vol 115 | No. 4 | April 2021 | Page 881

Clinical implications of home-based sperm testing
Thomas A. Masterson, Premal Patel
Vol 115 | No. 4 | April 2021 | Page 882

Can artificial intelligence drive optimal sperm selection for in vitro fertilization?
Darshan P. Patel, Kelli X. Gross, James M. Hotaling
Vol 115 | No. 4 | April 2021 | Page 883

The influence of assisted reproductive technologies on obstetric and perinatal outcomes: the chicken, the egg, or both?
Luis R. Hoyos, Steven J. Ory
Vol 115 | No. 4 | April 2021 | Pages 884-885

Which protocol for frozen-thawed embryo transfer is associated with the best outcomes for the mother and baby?
Frauke von Versen-Höynck, Kirk P. Conrad, Valerie L. Baker
Vol 115 | No. 4 | April 2021 | Pages 886-887

Is it in our patients’ blood? On a quest for predictors of blastocysts’ aneuploidy rate
Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi
Vol 115 | No. 4 | April 2021 | Pages 888-889

Connecting the dots between oocyte quantity and quality in diminished ovarian reserve
David B. Seifer
Vol 115 | No. 4 | April 2021 | Page 890

In vitro fertilization oocyte retrieval: to “flush” or not?
Humberto Scoccia
Vol 115 | No. 4 | April 2021 | Page 891

One millimeter in the time of COVID
Bradley S. Hurst
Vol 115 | No. 4 | April 2021 | Page 892

The promised land of individualized ovarian stimulation: Are we there yet?
Helen H. Kim,Sedona E. Speedy
Vol 115 | No. 4 | April 2021 | Pages 893-894

Endometrial receptivity screening in the general assisted reproductive technology population
Richard T. Scott Jr.
Vol 115 | No. 4 | April 2021 | Pages 895-896

For the next 40 years of in vitro fertilization—let’s sharpen our focus on iatrogenic harm reduction
Pietro Bortoletto, Phillip A. Romanski
Vol 115 | No. 4 | April 2021 | Page 897

The journey toward personalized embryo selection algorithms
Marcos Meseguer, M. Ángeles Valera
Vol 115 | No. 4 | April 2021 | Pages 898-899

Endometriosis and spontaneous hemoperitoneum in pregnancy: ab uno disce omnes… Is it always true?
Olivier Donnez, Jacques Donnez
Vol 115 | No. 4 | April 2021 | Page 900

Insufficient fertility counseling and decisional regret: a call to raise our standards for fertility preservation counseling prior to gender-affirming care
Amanda R. Schwartz, Molly B. Moravek
Vol 115 | No. 4 | April 2021 | Pages 901-902

Using pharmacologic research to efficiently meet acute contraceptive needs
Aaron Lazorwitz, Stephanie Teal
Vol 115 | No. 4 | April 2021 | Pages 903-904

Circulating cytokines during the blastocyst peri-implantation period
Maria J. de los Santos, Diana Alecsandru
Vol 115 | No. 4 | April 2021 | Pages 905-906

Embryo-endometrium crosstalk: a new understanding from in vitro model
Tianren Wang, Xi Xia, William S.B. Yeung
Vol 115 | No. 4 | April 2021 | Pages 907-908

Resveratrol improves granulosa cell activity through mitochondrial biogenesis
Kathryn J. Grive, May-Tal Sauerbrun-Cutler
Vol 115 | No. 4 | April 2021 | Pages 909-910 

An insider perspective from Mayer-Rokitansky-Küster-Hauser syndrome patients on uterus transplantation
Mabel Lee, Ruth M. Farrell, Rebecca Flyckt
Vol 115 | No. 4 | April 2021 | Pages 911-912 

Live and let DIE: a closer look at deep infiltrating endometriosis
Vaishnavi Purusothaman, Audrey S. Garneau, Linnea R. Goodman
Vol 115 | No. 4 | April 2021 | Pages 913-914

Original Articles

Andrology

Efficacy of the second micro–testicular sperm extraction after failed first micro–testicular sperm extraction in men with nonobstructive azoospermia
Oktay Özman, Süleyman Tosun, Numan Bayazıt, Sami Cengiz, Mustafa Emre Bakırcıoğlu
Vol 115 | No. 4 | April 2021 | Pages 915-921

Development and validation of a novel mail-in semen analysis system and the correlation between one hour and delayed semen analysis testing
Mary K. Samplaski, Owen Falk, Stanton Honig, David Shin, William Matthews, James F. Smith
Vol 115 | No. 4 | April 2021 | Pages 922-929

Machine-learning algorithm incorporating capacitated sperm intracellular pH predicts conventional in vitro fertilization success in normospermic patients
Stephanie Jean Gunderson, Lis Carmen Puga Molina, Nicholas Spies, Paula Ania Balestrini, Mariano Gabriel Buffone, Emily Susan Jungheim, Joan Riley, Celia Maria Santi
Vol 115 | No. 4 | April 2021 | Pages 930-939

Assisted Reproduction

Obstetric and perinatal outcomes of in vitro fertilization and natural pregnancies in the same mother
Hadas Ganer Herman, Yossi Mizrachi, Ayala Shevach Alon, Yasmin Farhadian, Ohad Gluck, Jacob Bar, Michal Kovo, Arieh Raziel
Vol 115 | No. 4 | April 2021 | Pages 940-946 

Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET
Louise Laub Asserhøj, Anne Lærke Spangmose, Anna-Karina Aaris Henningsen, Tine Dalsgaard Clausen, Søren Ziebe, Rikke Beck Jensen, Anja Pinborg
Vol 115 | No. 4 | April 2021 | Pages 947-956

Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization
Brent M. Hanson, Xin Tao, Yiping Zhan, Julia G. Kim, M.D., Amber M. Klimczak, Nola S. Herlihy, Richard T. Scott Jr., Emre Seli
Vol 115 | No. 4 | April 2021 | Pages 957-965

Diminished ovarian reserve is associated with reduced euploid rates via preimplantation genetic testing for aneuploidy independently from age: evidence for concomitant reduction in oocyte quality with quantity
Eleni Greenwood Jaswa, Charles E. McCulloch, Rhodel Simbulan, Marcelle I. Cedars, Mitchell P. Rosen
Vol 115 | No. 4 | April 2021 | Pages 966-973

Follicle flushing does not improve live birth and increases procedure time: a systematic review and meta-analysis of randomized controlled trials
Anne E. Martini, Ariel Dunn, Lauren Wells, Nanette Rollene, Rhiana Saunders, Mae W. Healy, Nancy Terry, Alan DeCherney, Micah J. Hill
Vol 115 | No. 4 | April 2021 | Pages 974-983

Optimal lead follicle size for human chorionic gonadotropin trigger in clomiphene citrate and intrauterine insemination cycles: an analysis of 1,676 treatment cycles
Kolbe L. Hancock, Nigel Pereira, Paul J. Christos, Allison C. Petrini, Jennifer Hughes, Pak H. Chung, Zev Rosenwaks
Vol 115 | No. 4 | April 2021 | Pages 984-990

Individualized ovarian stimulation for in vitro fertilization: a multicenter, open label, exploratory study with a mixed protocol of follitropin delta and highly purified human menopausal gonadotropin
Francois Bissonnette, Jaume Minano Masip, Isaac-Jacques Kadoch, Clifford Librach, John Sampalis, Albert Yuzpe
Vol 115 | No. 4 | April 2021 | Pages 991-1000

Routine endometrial receptivity array in first embryo transfer cycles does not improve live birth rate
Carrie Riestenberg, Lindsay Kroener, Molly Quinn, Kaycee Ching, Gayane Ambartsumyan
Vol 115 | No. 4 | April 2021 | Pages 1001-1006

Complications of the third stage of labor in in vitro fertilization pregnancies: an additional expression of abnormal placentation?
Hadas Ganer Herman, Yasmin Farhadian, Ayala Shevach Alon, Yossi Mizrachi, Dean Ariel, Arieh Raziel, Jacob Bar, Michal Kovo
Vol 115 | No. 4 | April 2021 | Pages 1007-1013

An investigation into the effect of potential confounding patient and treatment parameters on human embryo morphokinetics
Amy Barrie, Garry McDowell, Stephen Troup
Vol 115 | No. 4 | April 2021 | Pages 1014-1022

Endometriosis

Endometriosis and spontaneous hemoperitoneum in pregnancy: evaluation of the magnitude of the risk in women becoming pregnant via in vitro fertilization
Laura Benaglia, Marco Reschini, Irene La Vecchia, Giorgio Candotti, Edgardo Somigliana, Paolo Vercellini
Vol 115 | No. 4 | April 2021 | Pages 1023-1028

Fertility Preservation 

Access, barriers, and decisional regret in pursuit of fertility preservation among transgender and gender-diverse individuals
Nina Vyas, Christopher R. Douglas, Christopher Mann, Amy K. Weimer, Molly M. Quinn
Vol 115 | No. 4 | April 2021 | Pages 1029-1034

Gynecology 

Clinical trial to evaluate pharmacokinetics and pharmacodynamics of medroxyprogesterone acetate after subcutaneous administration of Depo-Provera
Vera Halpern, Vivian Brache, Douglas Taylor, Anja Lendvay, Leila Cochón, Jeffrey T. Jensen, Laneta J. Dorflinger
Vol 115 | No. 4 | April 2021 | Pages 1035-1043

Reproductive Science

Successful implantation is associated with a transient increase in serum pro-inflammatory cytokine profile followed by a switch to anti-inflammatory cytokine profile prior to confirmation of pregnancy
Yiwei Zhao, Tao Zhang, Xi Guo, Chun Kwok Wong, Xiaoyan Chen, Yiu Leung Chan, Chi Chiu Wang, Susan Laird, Tin Chiu Li
Vol 115 | No. 4 | April 2021 | Pages 1044-1053

Reproductive Science 

Emerging role of embryo secretome in the paracrine communication at the implantation site: a proof of concept
Alice Luddi, Valentina Pavone, Laura Governini, Angela Capaldo, Claudia Landi, Francesca Ietta, Eugenio Paccagnini, Giuseppe Morgante, Vincenzo De Leo, Paola Piomboni
Vol 115 | No. 4 | April 2021 | Pages 1054-1062

Resveratrol depolarizes the membrane potential in human granulosa cells and promotes mitochondrial biogenesis
Francesco Ragonese, Lorenzo Monarca, Antonella De Luca, Loretta Mancinelli, Monica Mariani, Cristina Corbucci, Sandro Gerli, Rossana Giulietta Iannitti, Lucio Leonardi, Bernard Fioretti
Vol 115 | No. 4 | April 2021 | Pages 1063-1073

Reproductive Surgery 

Perspectives of 281 patients with Mayer-Rokitansky-Küster-Hauser Syndrome on uterine transplantation
Nicole Fischer, Helen Xun, Amy Lossie, Darya Fadavi, Halley Darrach, Pooja Yesantharao, Franca Kraenzlin, Bhuchitra Singh, Justin M. Sacks, James H. Segars
Vol 115 | No. 4 | April 2021 | Pages 1074-1083 

Video

Surgical treatment of deep endometriosis with adenomyosis externa: a challenging case in an infertile woman
Carlo Alboni, Ludovica Camacho Mattos, Laura Botticelli, Stefania Malmusi, Fabio Facchinetti, Annarita Pecchi
Vol 115 | No. 4 | April 2021 | Pages 1084-1086

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.