A sweet and steady future---long-term storage of gametes and gonadal tissues in trehalose glass at room temperature

Looking into the Crystal Ball

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VOLUME 1, ISSUE 2, P113-114, NOVEMBER 01, 2020


Pierre Comizzoli, D.V.M., Ph.D.


Our scientific community still relies on expensive, low temperature methods for preserving biomaterials—from DNA samples, to blood products, to germ cells and reproductive tissues. Currently, samples are processed and stored using classic approaches: in electrical subzero freezers or liquid nitrogen containers that require complex maintenance, alarms and specialized rooms with back-up power and HVAC systems. Unfortunately, electricity and liquid nitrogen are costly and not always readily available in some regions of the world. Contemporary cryostorage systems also are prone to failures—from human error to equipment breakdown—which has recently led to dramatic sample losses in human fertility clinics. Another major concern is the extreme sensitivity and specificities of tissues, cells, organelles, and DNA to cryoprotectants and low temperature exposures, lessons we have learned from years of studies (1, 2).

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.