A randomized controlled trial to evaluate the use of a web-based application to manage medications during in vitro fertilization

A randomized controlled trial evaluating a web-based application for in vitro fertilization medication management did not reduce patient communication or medication errors but revealed a surplus of medication for most patients.

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VOLUME 116, ISSUE 3, P793-800


Caitlin Elizabeth Martin, M.D., Michael Lanham, M.D., Alison Almgren-Bell, B.S., Courtney Marsh, M.D., Kenan Omurtag, M.D.



To evaluate the use of a web-based application that assists in medication management during in vitro fertilization (IVF) treatment.


Multicenter randomized controlled trial.


University hospitals.


Women undergoing IVF.


Subjects were recruited to assess quality of life during IVF and were randomly assigned to use either the OnTrack application to assist with medication management or conventional medication management. Surveys were administered at four time points.

Main Outcome Measure(s)

Medication surplus, incidence of medication errors, amount of patient-initiated communication, and patient satisfaction.


A total of 153 women participated. The average number of portal messages and telephone calls was similar between groups. Twelve patients in the control group (12/69, 17.4%) and 8 patients in the case group (8/72, 11.1%) made medication errors. There were similar amounts of medication surplus in the two groups. The estimated cost of medication waste was $2,578 ± $2,056 in the control group and $2,554 ± $1,855 in the case group. Patient satisfaction was similar between the two groups.


Use of a web-based application did not decrease medication errors, medication surplus, or patient-initiated messages. Many patients had a medication surplus, which can be an area of cost reduction during IVF.

Clinical Trial Registration Number

Clinicaltrials.gov NCT03383848.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.