A live birth with unexpectedly low serum human chorionic gonadotropin level on day 11 after blastocyst embryo transfer: a case report

Case Reports

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Volume 1, Issue 1, Pages 48–50

Authors:

Qizhen Zheng, M.D., Shiru Xu, M.D., Meilan Mo, M.D., Jing You, B.D., Yong Zeng, M.D.

Abstract:

Objective

To report a very rare case of live birth with unexpectedly low serum hCG level on day 11 after blastocyst embryo transfer.

Design

Case report.

Setting

Private infertility center.

Patient(s)

A 30-year-old nulliparous woman presented with PCOS and 1 year of infertility.

Interventions(s)

Conventional IVF was scheduled and a long-acting agonist protocol was selected.

Main Outcome Measure(s)

Maternal serum hCG levels and transvaginal ultrasound exams for the embryo’s well-being.

Result(s)

The hCG level was 11.6 IU/L on day 11 after the transfer of two blastocyst embryos, which was considered as either failing or extrauterine pregnancy. After blood titration, there were delayed hCG increases. A series of transvaginal ultrasounds also indicated a delayed but normal-appearing intrauterine pregnancy. A healthy baby boy was delivered at term by means of cesarean section.

Conclusion(s)

A low initial serum hCG level may be associated with certain maternal or fetal characteristics and IVF treatment variables. Close conservative observation is warranted before undertaking any therapeutic intervention.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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