Ongoing pregnancy rates in intrauterine insemination are affected by late follicular phase progesterone levels

Significant differences in ongoing pregnancy rates with high P levels after stimulated IUI cycles may help clinicians counsel patients about reduced success rates and time insemination to optimize implantation.

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Authors

Antonio Requena, M.D., María Cruz, Ph.D., Alberto Pacheco, Ph.D., Juan Antonio García-Velasco, M.D.

Volume 104, Issue 4, Pages 879-883

Abstract

Objective:

To determine the relationship between serum P levels on the day of hCG administration and ongoing pregnancy rates.

Design:

Retrospective study.

Setting:

University-affiliated private IVF setting belonging to IVI group in Spain.

Patient(s):

A total of 2,458 couples undergoing IUI.

Intervention(s):

Ovarian stimulation with human recombinant FSH.

Main Outcome Measure(s):

Ongoing pregnancy and miscarriage rates.

Result(s):

Progesterone concentrations were significantly higher given that the E2 concentration increased. Ongoing pregnancy rates were significantly decreased in women with P levels higher than 1.1 ng/mL; similar results were obtained in relation to miscarriage rates.

Conclusion(s):

Significant differences in ongoing pregnancy rates when P levels were elevated on the day of hCG administration may help clinicians to counsel patients about the reduced success rates with IUI and manage the timing of insemination to optimize implantation.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)00453-7/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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