Antimullerian hormone as a predictor of good-quality supernumerary blastocyst cryopreservation among women with levels <1 ng mL versus 1 4 ng mL

Antimullerian hormone (AMH) levels <1 ng/mL are associated with a statistically significantly lower likelihood of supernumerary good-quality blastocyst cryopreservation as compared with AMH levels between 1 and 4 ng/mL.

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Authors

Shahryar K. Kavoussi, M.D., M.P.H., Kate C. Odenwald, M.S.N., R.N., Lynn M. Boehnlein, B.S., Roxanne B. Summers-Colquitt, M.S., Thomas B. Pool, Ph.D., Jason E. Swain, Ph.D., Jeffrey M. Jones, Ph.D., Mary J. Lindstrom, Ph.D., Dan I. Lebovic, M.D.

Volume 104, Issue 3, Pages 633-636

Abstract

Objective:

To determine whether antimüllerian hormone (AMH) levels predict the availability of good-quality supernumerary blastocysts for cryopreservation.

Design:

Retrospective study.

Setting:

Two fertility centers.

Patient(s):

First fresh IVF cycles (n = 247) grouped as follows: 40 women <35 year old with AMH <1 ng/mL and 77 women with AMH of 1–4 ng/mL; 62 women ≥35 year old with AMH <1 ng/mL, and 68 women with AMH 1–4 ng/mL. Intervention(s):

AMH level measured before IVF with ovarian stimulation protocols based on patient age and AMH level, including short gonadotropin-releasing hormone (GnRH) agonist, GnRH antagonist, or GnRH agonist microdose flare; supernumerary good-quality blastocysts cryopreserved on days 5 or 6 after retrieval.

Main Outcome Measures(s):

Supernumerary good-quality blastocysts for cryopreservation in relation to AMH levels.

Result(s):

Among women <35 years of age, there was a statistically significant difference in the number of supernumerary good-quality blastocysts for cryopreservation between the groups with AMH <1 ng/mL and AMH of 1–4 ng/mL (30.0% vs. 58.4%) when adjusted for age. Among women ≥35 years of age, there was a statistically significant difference in the number of supernumerary good-quality blastocyst cryopreservation between groups with AMH <1 ng/mL and AMH of 1–4 ng/mL (16.1% vs. 42.6%), when adjusted for age. Conclusion(s):

Low AMH levels are associated with a statistically significantly lower likelihood of blastocysts for cryopreservation as compared with higher AMH levels. This effect was seen among women both <35 and ≥35 years of age. Patient counseling should include realistic expectations for the probability of good-quality supernumerary blastocysts available for cryopreservation.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)00429-X/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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