Aging and the environment affect gamete and embryo potential: can we intervene?

A discussion of the enhancing factors contributing to gamete competence and the mitigating factors reducing gamete (and therefore embryo) potential promise to reduce the number of euploid embryos failing to produce normal viable deliveries.


David R. Meldrum, M.D., Robert F. Casper, M.D., Antonio Diez-Juan, Ph.D., Carlos Simon, M.D., Ph.D., Alice D. Domar, Ph.D., Rene Frydman, M.D., Ph.D.

Volume 105, Issue 3, Pages 548-559


Optimal maturation of the oocyte depends on its environment and determines embryo competence, because the embryonic genome is not active until the cleavage stage and new mitochondria are not produced until blastulation. Adverse environmental factors include aging, andropause, oxidative stress, obesity, smoking, alcohol, and psychologic stress, whereas androgen supplementation, a prudent diet, exercise, nutritional supplements, and psychologic interventions have beneficial effects. Mitochondrial function and energy production deteriorate with age, adversely affecting ovarian reserve, chromosome segregation, and embryo competence. In aging mice, the mitochondrial cofactor coenzyme Q10 reverses most of these changes. Early human experience has been encouraging, although only a small study using a shorter duration of intervention compared with the murine model has been carried out. Mitochondrial metabolic stress can result in an abnormal compensatory increase in mitochondrial DNA, which can be assessed in biopsied blastomeres of trophectoderm as a predictive biomarker of implantation failure. Psychologic stress may reduce oocyte competence by shifting blood flow away from the ovary as part of the classic “fight or flight” physiologic response, and methods to reduce stress or the body’s reaction to stress improve pregnancy success. Enhancing oocyte competence is a key intervention that promises to reduce the number of euploid embryos failing to produce viable deliveries.

Read the full text at: