Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome Summary of a Cochrane review

We conducted a systematic review of the use of metformin as a cotreatment during in vitro fertilization and during intracytoplasmic sperm injection in women with polycystic ovary syndrome.

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Leopoldo O. Tso, M.D., Michael F. Costello, M.B.B.S., Luiz Eduardo T. Albuquerque, M.D., Régis B. Andriolo, Ph.D., Jane Marjoribanks, M.P.H., Cristiane R. Macedo, Ph.D.

Volume 104, Issue 3, Pages 542-544


In women with polycystic ovary syndrome, metformin treatment before or during assisted reproductive technology cycles increases clinical pregnancy rates and decreases the risk of ovarian hyperstimulation syndrome. However, there is no conclusive evidence of a benefit in live birth rates.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.