March 2016

Examining the many potential reasons why euploid blastocysts do not always result in viable pregnancies: part 1

The environment surrounding the oocyte and embryo from months before ovarian stimulation to embryo transfer profoundly affects the proportion of euploid embryos that fail to result in viable pregnancies.

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Fertility and Sterility
Editorial Office, American Society for Reproductive Medicine
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Authors

David R. Meldrum, M.D.

Volume 105, Issue 3, Pages 545-547

Abstract

The environment of the oocyte and embryo includes the metabolic effects of aging, lifestyle issues, psychological stress, nutritional supplements/replacements, cellular energy levels, endocrine and paracrine factors, the cumulus, exogenous gonadotropins and adjunctive medications, culture media, and the in vitro fertilization laboratory’s conditions and manipulations. These complex factors, which will be examined in the following series of reviews, explain in part why not all euploid blastocysts result in viable pregnancies.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)02176-7/fulltext

Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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