A sweet view of reproduction

In recent years, the advent of ‘omics’ has permitted large-scale molecular comparisons of cells, tissues, and secretions under different conditions. In reproductive medicine, ovarian and breast cancer, endometriosis, infertility, and failed implantation contribute significantly to the global burden of diseases. Much focus has been given to genomic markers used to generate molecular signatures of cells and organs, but more than 50% of expressed proteins are further modified by cotranscriptional and posttranscriptional events, which may not be reflected in altered gene expression profiles alone.

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Authors

Steven R. Lindheim, M.D., M.M.M., Pascal Gagneux, Ph.D.

Volume 104, Issue 3, Page 533

Abstract

In recent years, the advent of ‘omics’ has permitted large-scale molecular comparisons of cells, tissues, and secretions under different conditions. In reproductive medicine, ovarian and breast cancer, endometriosis, infertility, and failed implantation contribute significantly to the global burden of diseases. Much focus has been given to genomic markers used to generate molecular signatures of cells and organs, but more than 50% of expressed proteins are further modified by cotranscriptional and posttranscriptional events, which may not be reflected in altered gene expression profiles alone.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)00431-8/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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