Dorothée Poidatz, Ph.D., Esther Dos Santos, Ph.D., Fabien Duval, B.S., Hadia Moindjie, B.S., Valérie Serazin, M.D., Ph.D., François Vialard, M.D., Ph.D., Philippe De Mazancourt, M.D., Ph.D., Marie-Noëlle Dieudonné, Ph.D.
Volume 104, Issue 2, Pages 483-490
To measure mitochondrial content and the expression of estrogen-related receptor-γ (ERRγ, a major inducer of mitochondrial biogenesis) in placentas from women with intrauterine growth restriction (IUGR) associated or not with pre-eclampsia (PE), relative to control placentas.
Teaching hospital and university research laboratory.
Thirty-nine placentas from women with IUGR, 8 IUGR+PE, and 30 controls.
Main Outcome Measure(s):
Mitochondrial DNA and protein content, gene and protein expression.
We observed significantly lower placental mitochondrial DNA and protein contents (associated with down-regulation of ERRγ expression) in IUGR and IUGR+PE placentas, relative to control placentas. Our results also revealed that the placental mitochondrial DNA content was directly correlated with fetal weight. Moreover, we observed significantly lower peroxisome proliferator-activated receptor-γ coactivator-1α and sirtuin 1 messenger RNA expression levels in IUGR+PE placentas, relative to control placentas.
The low mitochondrial DNA and protein contents observed in IUGR placentas are probably due to down-regulation of ERRγ expression. This finding suggests that ERRγ has a major role in the control of placental development.
Read the full text at: http://www.fertstert.org/article/S0015-0282(15)00351-9/fulltext