Mild ovarian stimulation with clomiphene citrate launch is a realistic option for in vitro fertilization

Mild stimulation using clomiphene citrate can be considered a realistic option to give patients with a good prognosis an excellent probability of pregnancy in a very short time period.

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Anna Pia Ferraretti, Ph.D., Luca Gianaroli, M.D., Maria Cristina Magli, M.Sc., Paul Devroey, Ph.D.

Volume 104, Issue 2, Pages 333-338



To validate the use of clomiphene citrate in IVF when mild stimulation approaches are chosen to reduce patient discomfort, risk, and cost.


Prospective cohort study.


Private IVF clinic.


A total of 163 patients undergoing IVF and with a good prognosis (defined as ≤38 years old with normal ovarian reserve and normovulatory cycles, body mass index


Mild stimulation using a fixed protocol of clomiphene citrate (100 mg/d from cycle days 3 to 7) in combination with low doses of gonadotropins (150 IU of recombinant FSH on cycle days 5, 7, and 9) and GnRH antagonist.

Main Outcome Measure(s):

The cumulative delivery rate per patient after three fresh and/or frozen embryo transfers and time to pregnancy.


No dropouts were observed. The cumulative delivery rate was 70%, and the mean time to pregnancy was 2.4 months.


Mild stimulation using clomiphene citrate in combination with low doses of gonadotropins can be considered a realistic option for good-prognosis patients undergoing IVF.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.