Randomized triple blind placebo controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men

Three months of supplementation with alpha-lipoic acid improved sperm quality in infertile men. Medical therapy with oral antioxidants can improve quality of semen parameters.

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Hossein Khadem Haghighian, Fatemeh Haidari, Ph.D., Javad Mohammadi-asl, Ph.D., Mohammadreza Dadfar, M.D.

Volume 104, Issue 2, Pages 318-324



To evaluate effects of supplementation with alpha-lipoic acid (ALA) on the spermatogram and seminal oxidative stress biomarkers.


Randomized, triple-blind, placebo-controlled clinical trial.


Infertility clinic.


Infertile men.


ALA (600 mg) or placebo for 12 weeks.

Main Outcome Measure(s):

Semen analysis, anthropometric, dietary, and physical activity assessments, total antioxidant capacity, and malondialdehyde.


At the end of study, the total sperm count, sperm concentration, and motility in the intervention group were significantly higher than in the control group. In the ALA group, the total sperm count, sperm concentration, and motility levels were also significantly increased at the end of study compared with baseline values. However, there were no significant differences in ejaculate volume, normal morphology percentage, and live sperm between groups. ALA supplementation also resulted in a significant improvement in seminal levels of total antioxidant capacity (TAC) and malondialdehyde compared with the placebo.


According to the results, medical therapy of asthenoteratospermia with ALA supplement could improve quality of semen parameters. However, further investigation is suggested in this regard.

Clinical Trial Registration Number:


Read the full text at: http://www.fertstert.org/article/S0015-0282(15)00361-1/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.