Gestational hypothyroidism Development of mild hypothyroidism in early pregnancy in previously euthyroid women

Previously euthyroid women with infertility or recurrent pregnancy loss and negative thyroid peroxidase antibodies had a 24% incidence of hypothyroidism (TSH 2.5) at the time of pregnancy detection.

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Authors

Karen R. Hammond, D.N.P., C.R.N.P., Nicholas A. Cataldo, M.D., M.P.H., Janice A. Hubbard, Beth A. Malizia, M.D., Michael P. Steinkampf, M.D.

Volume 103, Issue 6, Pages 1532-1536

Abstract

Objective:

To determine the proportion of euthyroid women attending a fertility practice who develop hypothyroidism in very early pregnancy (gestational hypothyroidism [GHT]), and to examine the association of GHT with exogenous gonadotropin treatment.

Design:

Retrospective cohort study.

Setting:

A private reproductive medicine practice.

Patient(s):

All healthy women (N = 94) with infertility or recurrent pregnancy loss, TSH level

Intervention(s):

Usual fertility care; 30 women who had received exogenous gonadotropins.

Main Outcome Measure(s):

Serum TSH level at the time of pregnancy detection.

Result(s):

Gestational hypothyroidism (TSH ≥ 2.5 mIU/L) developed in 23 of 94 women (24%). The mean increase in serum TSH level from initial evaluation to early pregnancy was 0.45 ± 0.08 [SE] mIU/L. There was a trend toward the association of GHT with use of exogenous gonadotropins. Gestational hypothyroidism was positively associated with initial prepregnancy TSH level.

Conclusion(s):

Euthyroid women may develop mild hypothyroidism in early pregnancy, especially after exogenous gonadotropin treatment. Appropriate vigilance will allow for timely levothyroxine treatment.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)00205-8/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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