Should progesterone on the human chorionic gonadotropin day still be measured?

In 1,901 IVF cycles, a cut-off value of P on the hCG day differentiating good- from poor-prognosis cycles was not identified; therefore, clinical decisions should be based on other individual circumstances.


Francisca Martinez, Ph.D., Ignacio Rodriguez, B.Sc., Marta Devesa, M.D., Rosario Buxaderas, M.D., Maria José Gómez, B.Sc., Buenaventura Coroleu, Ph.D.

Volume 105, Issue 1, Pages 86-92



To evaluate in our setting whether there is currently a level of P on the hCG day (P-hCG) predictive of no pregnancy.


Observational study of prospectively collected data of the P-hCG levels of stimulated IVF cycles.


In vitro fertilization unit.


All cycles of IVF/intracytoplasmic sperm injection with fresh embryo transfer performed between January 2009 and March 2014.



Main Outcome Measure(s):

Pregnancy rate.


Clinical pregnancy rate per ET was 38.7% and live birth rate was 29.1%. The P-hCG concentration was positively correlated to E2 on the hCG day, and the number of oocytes was negatively correlated to age. Progesterone on hCG day was higher among agonist- compared with antagonist-treated patients (1.13 ± 0.69 ng/mL vs. 0.97 ± 0.50 ng/mL) and among recombinant FSH compared with recombinant FSH + hMG stimulation (1.11 ± 0.58 ng/mL vs. 0.94 ± 0.50 ng/mL). Pregnancy rate was positively associated with the number of oocytes. There was no correlation between P-hCG value and pregnancy rate, overall or according to the type of treatment.


In our setting there is no P-hCG value differentiating a good from a poor cycle success rate.

Clinical Trial Registration Number:


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