Relationship between sperm aneuploidy sperm DNA integrity chromatin packaging traditional semen parameters and recurrent pregnancy loss

The increase in abnormal sperm parameters, sperm DNA fragmentation, chromatin decondensation, and aneuploidy suggest possible causes of unexplained recurrent pregnancy loss, which encourage the screening of both partners simultaneously.

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Authors

Ines Zidi-Jrah, M.D., Amani Hajlaoui, M.Sc., Soumaya Mougou-Zrelli, M.D., Ph.D., Molka Kammoun, M.D., Imene Meniaoui, M.D., Amira Sallem, M.D., Sonia Brahem, Ph.D., Meriem Fekih, M.D., Mohammed Bibi, M.D., Ali Saad, M.D., Ph.D., Samira Ibala-Romdhane, M.D., Ph.D.

Volume 105, Issue 1, Pages 58-64

Abstract

Objective:

To study the possible relationship between sperm aneuploidy, sperm DNA integrity, chromatin packaging, traditional semen parameters, and recurrent pregnancy loss (RPL).

Design:

Descriptive study.

Setting:

University-affiliated tertiary teaching hospital, cytogenetic and reproductive biology department.

Patient(s):

A total of 22 couples with history of RPL and 20 fertile men.

Intervention(s):

Semen samples from case and control men were examined for differences in semen parameters, DNA fragmentation, chromatin condensation, and sperm aneuploidy.

Main Outcome Measure(s):

Sperm DNA and chromatin integrity and sperm aneuploidy.

Result(s):

Sperm progressive motility (30.2% vs. 51.5%) was significantly lower and abnormal morphology (74.8% vs. 54.2%) was significantly higher in the RPL group versus the control group, respectively. The percentage of fragmented DNA was significantly increased in the RPL group (17.1% vs. 10.2%) as well as the rate of spermatozoa with nuclear chromatin decondensation (23.6% vs. 11.8%). There was a significantly higher sperm aneuploidy rate among the RPL group as well.

Conclusion(s):

The increase in abnormal sperm parameters, sperm DNA fragmentation, nuclear chromatin decondensation, and sperm aneuploidy suggest possible causes of unexplained RPL.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)02005-1/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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