Paternal age and mental health of offspring

Paternal aging predicts increasing risks for offspring schizophrenia, autism, bipolar disorder, and other behavioral conditions. De novo mutations are implicated, but other interrelated factors are being studied, including paternal age at marriage, duration of marriage, and maternal age.

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Authors

Dolores Malaspina, M.D., M.S.P.H., Caitlin Gilman, M.D., M.P.H., Thorsten Manfred Kranz, Ph.D.

Volume 103, Issue 6, Pages 1392-1396

Abstract

The influence of paternal age on the risk for sporadic forms of Mendelian disorders is well known, but a burgeoning recent literature demonstrates, in addition, a paternal age effect for complex neuropsychiatric conditions, including schizophrenia, autism, bipolar disorder, and even for learning potential, expressed as intelligence. Mental illness is costly to patients, their family, and the public health system, accounting for the largest portion of disability costs in our economy. The delayed onset of neuropsychiatric conditions and lack of physical manifestations at birth are common frequencies in the population that have obscured the recognition that a portion of the risks for mental conditions is associated with paternal age. Identification of these risk pathways may be leveraged for knowledge about mental function and for future screening tests. However, only a small minority of at-risk offspring are likely to have such a psychiatric or learning disorder attributable to paternal age, including the children of older fathers.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)00288-5/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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