Does ovarian reserve predict egg quality in unstimulated therapeutic donor insemination cycles?

Antral follicle count is not predictive of pregnancy or miscarriage in patients undergoing unstimulated therapeutic donor insemination cycles for indications of an azoospermic male partner or the absence of a male partner.

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Mike Ripley, M.D., F.R.C.S.C., Andrea Lanes, M.Sc., Marie-Claude Léveillé, Ph.D., Doron Shmorgun, M.D., F.R.C.S.C.

Volume 103, Issue 5, Pages 1170-1175



To compare reproductive outcomes of patients with very low, low, normal, and high antral follicle counts undergoing unstimulated therapeutic donor insemination (TDI) cycles.


Retrospective cohort study.


University-affiliated regional fertility clinic.


Four hundred fifty-nine patients who had 1,107 TDI treatment cycles from January 2006 to December 2013.


Unstimulated therapeutic donor insemination.

Main Outcome Measure(s):

Clinical pregnancy rates and miscarriage rates as surrogate markers for oocyte quality.


The overall pregnancy rate per cycle start was 12.46% in the study population. There was no difference in per-cycle or cumulative pregnancy rates among patients with very low, low, average, or high antral follicle counts within each patient age group of ≤35, 36–39, and ≥40 years. The overall miscarriage rate per pregnancy was 13.61%. When stratified by patient age, there was no correlation between miscarriage rate and antral follicle count.


AFC is not a predictor of pregnancy or miscarriage rates in patients undergoing unstimulated TDI.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.