Loop electrosurgical excision procedure and risk of miscarriage

Women with a time interval from LEEP to pregnancy of


Andrea Ciavattini, M.D., Nicolò Clemente, M.D., Giovanni Delli Carpini, M.D., Chiara Gentili, M.D., Jacopo Di Giuseppe, M.D., Pamela Barbadoro, M.D., Emilia Prospero, M.D., Carlo Antonio Liverani, M.D.

Volume 103, Issue 4, Pages 1043-1048



To evaluate the risk of miscarriage in the subsequent pregnancy after a loop electrosurgical excision procedure (LEEP), also considering time elapsed from LEEP to pregnancy.


Multicenter, retrospective cohort study.


Tertiary care university hospitals.


Women who had undergone LEEP from January 2000 to December 2011. Women with histologic assessment of low-grade cervical dysplasia, not requiring subsequent surgical treatment, constituted the control group.



Main Outcome Measure(s):

The first pregnancy after the procedure was evaluated, and only women with singleton spontaneous pregnancies were considered. Women with time intervals of


In women previously treated with LEEP, a total of 116 cases of miscarriage (18.1%) was reported. The mean time interval from LEEP to pregnancy for women with miscarriage compared with women without miscarriage was significantly shorter (25.1 ± 11.7 months vs. 30.1 ± 13.3 months). A higher rate of miscarriage in women with a LEEP-to-pregnancy interval of


Women with a time interval from LEEP to pregnancy of

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