Association of body mass index with embryonic aneuploidy

Body mass index was not associated with the number or percent of euploid embryos in patients undergoing 24-chromosome pre-implantation genetic screening.

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Authors

Kara N. Goldman, M.D., Brooke Hodes-Wertz, M.D., M.P.H., David H. McCulloh, Ph.D., Julie D. Flom, M.P.H., Jamie A. Grifo, M.D., Ph.D.

Volume 103, Issue 3, Pages 744-748

Abstract

Objective:

To determine whether an association exists between body mass index (BMI) and embryo ploidy in patients undergoing in vitro fertilization (IVF) with trophectoderm biopsy and 24-chromosome preimplantation genetic screening (PGS).

Design:

Retrospective cohort study.

Setting:

University-based fertility center.

Patient(s):

279 women aged 20–45 years with documented height and weight from the day of oocyte retrieval who underwent 24-chromosome PGS between 2010 and 2013.

Intervention(s):

None.

Main Outcome Measure(s):

Primary outcomes: number and percentage of euploid embryos.

Result(s):

Patients were grouped by World Health Organization (WHO) BMI class: underweight (<18.5, n = 11), normal weight (18.5–24.9, n = 196), overweight (25–29.9, n = 50), and obese (≥30, n = 22). Groups were similar by age (mean ± standard error of the mean: 37.5 ± 1.2 to 39.2 ± 0.9), ovarian reserve, and IVF cycle parameters. There was no difference in the number or percentage of euploid embryos by BMI category (

Conclusion(s):

No statistically significant relationship was identified between BMI and euploidy in an otherwise homogenous cohort of patients undergoing IVF with PGS, suggesting that the negative impact of overweight and obesity on IVF and reproductive outcomes may not be related to aneuploidy.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02385-1/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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