Hepatitis B virus infection and the risk of male infertility A population based analysis

This population-based study demonstrated a significantly increased risk of developing male infertility among HBV carriers (hazard ratio 1.52).

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Fu-Hsiung Su, B.M.B.S., Ph.D., Shih-Ni Chang, M.S.P.H., Fung-Chang Sung, Ph.D., M.P.H., Chien-Tien Su, M.D., Ph.D., Ying-Hua Shieh, M.D., Cheng-Chieh Lin, M.D., Ph.D., Chih-Ching Yeh, Ph.D., M.S.P.H.

Volume 102, Issue 6, Pages 1677-1684



To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection.


A nationwide, population-based cohort study.


Not applicable.


Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690).



Main Outcome Measure(s):

Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification.


The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20–1.92) after adjusting for covariates in a multivariate Cox proportional hazards model.


The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02169-4/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.