Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients

Vitamin D insufficiency or deficiency does not influence implantation and pregnancy rates in oocyte recipients.


Alberta Fabris, M.D., Alberto Pacheco, Ph.D., María Cruz, Ph.D., Jose Manuel Puente, M.D., Human Fatemi, M.D., Juan A. Garcia-Velasco, M.D., Ph.D.

Volume 102, Issue 6, Pages 1608-1612



To investigate the correlation between total and bioavailable serum 25-OH vitamin D and the pregnancy rate in recipients of donated oocytes.


Retrospective study.


University-affiliated private IVF center.


A total of 267 patients who were referred to our clinic for oocyte donation from June 2013 to December 2013.


Serum analysis of vitamin D and bioavailable vitamin D and reproductive outcomes.

Main Outcome Measure(s):

Pregnancy and implantation rate.


Among all patients, 15.3% (n = 41) were vitamin D replete (vitamin D >30 ng/mL), 50.2% (n = 134) had vitamin D deficiency (20–30 ng/mL), and 34.4% (n = 92) had insufficient vitamin D (


Vitamin D insufficiency and deficiency are frequent conditions in our southern European infertile population. In contrast to previous studies, patients who are not vitamin D replete do not have a decreased chance of becoming pregnant with egg donation. Bioavailable 25-OH vitamin D, which is a better marker of the status than total 25-OH vitamin D, does not correlate with pregnancy rate in recipients of donated oocytes. Thus, at this stage, there is insufficient evidence to recommend vitamin D screening in patients undergoing egg donation.

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