First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids

The first series of pregnancies achieved after UPA treatment is reported.

Like Comment

Authors

Mathieu Luyckx, M.D., Jean-Luc Squifflet, M.D., Ph.D., Pascale Jadoul, M.D., Rafaella Votino, M.D., Marie-Madeleine Dolmans, M.D., Ph.D., Jacques Donnez, M.D., Ph.D.

Volume 102, Issue 5, Pages 1404–1409

Abstract

Objective:

To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.

Design:

Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.

Setting:

Academic hospital.

Patient(s):

Among the 52 patients, 21 wished to conceive upon treatment completion.

Intervention(s):

None.

Main Outcome Measure(s):

Pregnancy rate and live birth rate.

Result(s):

Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy.

Conclusion(s):

We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02024-X/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.