Using the Society for Assisted Reproductive Technology Clinic Outcome System morphological measures to predict live birth after assisted reproductive technology

There is a significant association between the embryo quality parameters reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System and live birth.

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Authors

Barbara Luke, Sc.D., M.P.H., Morton B. Brown, Ph.D., Judy E. Stern, Ph.D., Sangita K. Jindal, Ph.D., Catherine Racowsky, Ph.D., G. David Ball, Ph.D.

Volume 102, Issue 5, Pages 1338–1344

Abstract

Objective:

To model morphological assessments of embryo quality that are predictive of live birth.

Design:

Longitudinal cohort using cycles reported in the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) between 2007 and 2011.

Setting:

Clinic-based data.

Patient(s):

Fresh autologous assisted reproductive technology (ART) cycles with ETs on day 3 or day 5 and morphological assessments reported (25,409 cycles with one embryo transferred and 96,093 cycles with two embryos transferred). Live-birth rates were modeled by morphological assessments using backward-stepping logistic regression for cycle 1 and over five cycles, separately for day 3 and day 5 transfers and number of embryos transferred (1 or 2). Additional models for each day of transfer also included the number of oocytes retrieved and the number of embryos cryopreserved.

Intervention(s):

None.

Main Outcome Measure(s):

Live births.

Result(s):

Morphological assessments of grade, stage, fragmentation, and symmetry were significant for the day 3 models; grade, stage, and trophectoderm were significant in the day 5 model; inner-cell mass was significant in the models when two embryos were transferred. Number of oocytes retrieved and number of embryos cryopreserved were significant for both day 3 and day 5 models.

Conclusion(s):

These findings confirm the significant association between embryo quality parameters reported to SART CORS and live-birth rate after ART.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)01883-4/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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