Blastocyst euploidy and implantation rates in a young (<35 years) and old (≥35 years) presumed fertile and infertile patient population

Our data demonstrated no difference in euploid blastocyst rates between presumed fertile and infertile patients. Pregnancy and implantation rates were significantly higher in presumed fertile patients when transferring euploid blastocysts.

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Authors

Tyl H. Taylor, M.S., Jennifer L. Patrick, M.S., Susan A. Gitlin, Ph.D., Jack L. Crain, M.D., J. Michael Wilson, Ph.D., Darren K. Griffin, Ph.D.

Volume 102, Issue 5, Pages 1318–1323

Abstract

Objective

To examine the relationship between blastocyst euploidy and implantation rates in a presumed fertile patient population.

Design

Retrospective analysis.

Setting

Private IVF clinic.

Patient(s)

IVF patients undergoing comprehensive chromosome screening (CCS).

Intervention(s)

Embryo biopsy at the blastocyst stage with preimplantation genetic screening using CCS.

Main Outcome Measure(s)

Euploidy, chemical pregnancy, and implantation rates.

Result(s)

There was no significant difference in the number of euploid blastocysts between presumed fertile (68/118, 57.6%) and infertile (75/132, 56.8%) patients <35 years old. Likewise, there was no significant difference in the number of euploid blastocysts between presumed fertile (42/86, 48.8%) and infertile (97/206, 47.1%) patients ≥35 years old. When those same patients underwent a corresponding frozen embryo transfer cycle, presumed fertile patients demonstrated a significantly higher chemical pregnancy rate when compared with infertile patients, 28/33 (84.8%) and 50/81 (61.7%), respectively. Moreover, presumed fertile patients exhibited significantly higher implantation rates compared with infertile patients, 36/42 (85.7%) and 54/109 (66.7%), respectively.

Conclusion(s)

When subdivided by maternal age, no significant difference was seen in blastocyst euploidy rates between presumed fertile and infertile patients; however, chemical pregnancy and implantation rates were significantly higher in a presumed fertile patient population even when transferring only euploid blastocysts. This would indicate that infertility, as a disease, may encompass other aspects such as uterine or other unknown embryological factors that can influence outcomes.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)01834-2/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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