High body mass index has a deleterious effect on semen parameters except morphology: results from a large cohort study

In this large cohort study of 10,665 men, semen quality, including volume, sperm concentration, and progressive motility, decreased with increased body mass index. Morphology was unaffected.

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Authors

Stéphanie Belloc, Pharm.D., Martine Cohen Bacrie, M.D., Edouard Amar, M.D., Vincent Izard, M.D., Moncef Ben Khalifa, Ph.D., Alain Dalleac, M.D., Jacques de Mouzon, M.D., M.P.H.

Volume 102, Issue 5, Pages 1268-1273

Abstract

Objective:

To evaluate the influence of body mass index (BMI) on semen characteristics.

Design:

Cohort study.

Setting:

Single private andrology laboratory.

Patient(s):

All patients (n = 10,665) consulting for a semen analysis from October 9, 2010, to October 8, 2011. When analyses were repeated on the same patient, only the first was included.

Intervention(s):

Recording of self-reported weight and height and of semen analysis.

Main Outcome Measure(s):

All parameters of standard semen analysis: pH, volume, sperm concentration per mL, total sperm count per ejaculate, motility (%) within 1 hour after ejaculation (overall and progressive), viability (%), and normal sperm morphology (%). Parametric and nonparametric statistical methods were applied, and results are given either with mean ± SD, or 10th, 50th, and 90th percentiles.

Result(s):

Semen volume decreased from 3.3 ± 1.6 to 2.7 ± 1.6 mL when BMI increased from normal (20–25 kg/m2) to extreme obesity (>40 kg/m2). The same was true for semen concentration (56.4 ± 54.9 to 39.4 ± 51.0 million/mL), total sperm count (171 ± 170 to 92 ± 95 million), and progressive motility (36.9 ± 16.8% to 34.7 ± 17.1%). The percentage of cases with azoospermia and cryptozoospermia increased from 1.9% to 9.1% and from 4.7% to 15.2%, respectively. The other semen characteristics were not affected. Multivariate models including age and abstinence duration confirmed these results.

Conclusion(s):

In this study, on a large patient sample size, increased BMI was associated with decreased semen quality, affecting volume, concentration, and motility. The percentage of normal forms was not decreased.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)01839-1/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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