Resolvins RvD1 and 17R RvD1 alleviate signs of inflammation in a rat model of endometriosis

RvD1 and 17(R)-RvD1 reduced cyst vascular permeability and associated vaginal hyperalgesia in rats with surgically-induced endometriosis suggesting that further investigation of therapeutic anti-inflammatory potentials of resolvins can be considered.

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Authors

Natalia Dmitrieva, Ph.D., Gregory Suess, B.S., Russell Shirley, B.S.

Volume 102, Issue 4, Pages 1191-1197

Abstract

Objective:

To study the effects of two resolvins of D series, RvD1 and 17(R)-RvD1, on inflammatory signs associated with endometriosis (ENDO).

Design:

In vivo research study.

Setting:

Research laboratory.

Animal(s):

Female Sprague-Dawley rats.

Intervention(s):

Intravenous or intraperitoneal injections of RvD1 (300 ng/kg) or 17(R)-RvD1 (300 and 900 ng/kg) in rats with surgically induced ENDO.

Main Outcome Measure(s):

Vascular permeability of ectopic endometrial growths was assessed by Evans Blue extravasation; vaginal hyperalgesia was assessed with telemetered visceromotor response.

Result(s):

Both resolvins, but not vehicle, significantly decreased vascular permeability in ectopic endometrial tissue. 17(R)-RvD1 also significantly alleviated severity of vaginal hyperalgesia.

Conclusion(s):

Our results suggest that RvD1 and 17(R)-RvD1 can be considered for further investigation of their therapeutic potential for treating ENDO.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)00592-5/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility┬« is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.