Influence of follicle rupture and uterine contractions on intrauterine insemination outcome A new predictive model

Follicle rupture and the number of uterine contractions observed after intrauterine insemination are positively correlated with clinical pregnancy and live birth rates. A prediction model was built including these variables.

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Víctor Blasco, M.Sc., Nicolás Prados, Ph.D., Francisco Carranza, M.D., Cristina González-Ravina, Ph.D., Antonio Pellicer, M.D., Ph.D., Manuel Fernandez-Sanchez, M.D., Ph.D.

Volume 102, Issue 4, Pages 1034-1040



To correlate the detection of follicle rupture and the number of uterine contractions per minute with the outcome of IUI and to build a predictive model for the outcome of IUI including these parameters.


Retrospective cohort study.


Fertility clinic.


We analyzed data from 610 women who underwent homologous or donor double IUI from 2005 to 2010 and whose data of uterine contractions or follicle rupture were recorded.



Main Outcome Measure(s):

Live-birth rate.


Nine hundred seventy-nine IUI cycles were included. The detection of follicle rupture (odds ratio [OR], 1.98; 95% confidence interval [CI], 1.30–3.01) and the number of uterine contractions per minute (OR, 1.67; 95% CI, 1.02–2.74) assessed after the second insemination procedure of a double IUI were positively correlated with the live-birth rate. A multiple logistic regression model showed that sperm origin, maternal age, follicle count at hCG administration day, follicle rupture, and the number of uterine contractions observed after the second insemination procedure were significantly associated with the live-birth rate.


Follicle rupture and uterine contractions are associated with the success of an IUI cycle. This may open new possibilities to improve the methodology of IUI.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.