Obstetric and perinatal outcome of babies born from vitrified oocytes

Obstetric and perinatal outcomes from singleton and multiple pregnancies obtained using vitrified oocytes revealed lack of clinically relevant differences when compared with those achieved with fresh oocytes.


Ana Cobo, Ph.D, Vicente Serra, M.D., Nicolas Garrido, Ph.D., Inés Olmos, M.D., Antonio Pellicer, M.D., José Remohí, M.D.

Volume 102, Issue 4, Pages 1006-1015



To assess outcomes after oocyte vitrification on obstetric and perinatal outcomes compared with those achieved with fresh oocytes.


Retrospective cohort study.


Private university-affiliated IVF center.


Children born after use of vitrified oocytes (1,027 from 804 pregnancies) and fresh oocytes (1,224 from 996 pregnancies). Singleton and multiples pregnancies from own and donated ova were included.


Oocyte vitrification by the Cryotop method.

Main Outcome Measure(s):

Pregnancy, delivery, and neonatal outcomes.


Vitrification had no clinically relevant adverse effects on obstetric and perinatal outcomes after adjusting for potential confounders. No differences were found between the vitrified and fresh oocyte groups in the rate of obstetric problems (including diabetes, pregnancy-induced hypertension, preterm birth, anemia, and cholestasis), gestational age at delivery, birth weight, Apgar scores, birth defects, admission to neonatal intensive care unit (ICU), perinatal mortality, and puerperal problems. Only a greater number of invasive procedures (adjusted odds ratio 2.12; 95% confidence interval 1.41–3.20), and a reduced occurrence of urinary tract infection (adjusted odds ratio 0.51; 95% confidence interval 0.28–0.91), were observed in the vitrified oocytes group.


Although our data, the largest series to date, suggest that oocyte vitrification does not increase adverse obstetric and perinatal outcomes in children conceived with vitrified oocytes, further studies with larger samples are required to reinforce our conclusions.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)00565-2/fulltext