Fibroid growth and medical options for treatment

Fibroids are frequent benign clonal tumors, promoted by sex steroids. They reduce quality of life through bleeding and fertility. Current medical treatment option, including GnRH analogues and selective progesterone receptor modulators, are discussed.

Like Comment

Authors

Nathalie Chabbert-Buffet, M.D., Ph.D., Nathalie Esber, M.Sc., Philippe Bouchard, M.D.

Volume 102, Issue 3, Pages 630-639

Abstract

Although fibroids are common benign tumors, their impact on women’s quality of life can be considerable. The most frequent symptoms are uterine bleeding, resulting in anemia, and pelvic pain. Fibroids can be of genetic or hormonal origin or arise from intrauterine events. Current options for medical treatment include control of estradiol and progesterone production or action and are discussed in this review. Although curative treatment of fibroids relies on surgical strategies, the current trend is for uterine-sparing treatment to preserve fertility and avoid unnecessary surgery. Currently approved medical treatments include intrauterine progestin delivery to reduce uterine bleeding, GnRH analogues, and, more recently, selective progesterone receptor modulators to control uterine bleeding and reduce fibroid volume.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)01865-2/fulltext


Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.