Authors
Catherine A. VandeVoort, Ph.D., Kristin N. Grimsrud, D.V.M., Ph.D., Uros Midic, Ph.D., Namdori Mtango, Ph.D., Keith E. Latham, Ph.D.
Volume 103, Issue 2, Pages 560-569
Abstract
Objective:
To determine if binge ethanol consumption before ovulation affects oocyte quality, gene expression, and subsequent embryo development.
Design:
Binge levels of ethanol were given twice weekly for 6 months, followed by a standard in vitro fertilization cycle and subsequent natural mating.
Setting:
National primate research center.
Animal(s):
Adult female rhesus monkeys.
Intervention(s):
Binge levels of ethanol, given twice weekly for 6 months before a standard in vitro fertilization cycle with or without embryo culture. With in vivo development, ethanol treatment continued until pregnancy was identified.
Main Outcome Measure(s):
Oocyte and cumulus/granulosa cell gene expression, embryo development to blastocyst, and pregnancy rate.
Result(s):
Embryo development in vitro was reduced; changes were found in oocyte and cumulus cell gene expression; and spontaneous abortion during very early gestation increased.
Conclusion(s):
This study provides evidence that binge drinking can affect the developmental potential of oocytes even after alcohol consumption has ceased.
Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02311-5/fulltext