Sperm cryopreservation in adolescents and young adults with cancer Results of the French national sperm banking network (CECOS)

Sperm banking is possible in young adolescents. The discrepancy between cancer incidence and the proportion of adolescents referred for sperm banking highlights the need for a change in care policy.


Myriam Daudin, M.D., Nathalie Rives, M.D., Ph.D., Marie Walschaerts, Ph.D., Véronique Drouineaud, M.D., Ph.D., Ethel Szerman, Ph.D., Isabelle Koscinski, M.D., Ph.D., Florence Eustache, M.D., Ph.D., Jacqueline Saïas-Magnan, M.D., Aline Papaxanthos-Roche, M.D., Rosalie Cabry-Goubet, M.D., Florence Brugnon, M.D., Ph.D., Dominique Le Lannou, M.D., Ph.D., Claire Barthélémy, Pharm.D., Jean-Marc Rigot, M.D., Thomas Fréour, Pharm.D., Ph.D., Isabelle Berthaut, Ph.D., Sandrine Giscard d’Estaing, M.D., Ph.D., Françoise Touati, M.D., Marie-Claude Mélin-Blocquaux, M.D., Oxana Blagosklonov, M.D., Ph.D., Claire Thomas, M.D., Mohamed Benhamed, M.D., Ph.D., Françoise Schmitt, M.D., Jean-Marie Kunstmann, M.D., Patrick Thonneau, M.D., Ph.D., Louis Bujan, M.D., Ph.D.

Volume 103, Issue 2, Pages 478-486



To determine the feasibility of fertility preservation in adolescent males with cancer.


Large multicenter retrospective study of male patients ≤20 years from 23 centers of a national network of sperm banks over a 34-year period


Sperm banks.


A total of 4,345 boys and young men aged 11 to 20 years.


Age, cancer diagnosis, feasibility of sperm banking, and sperm parameters.

Main Outcome Measure(s):

Description of patients, and success of their fertility preservation.


We observed a mean yearly increase in referred patients of 9.5% (95% confidence interval, 9.1%–9.8%) between 1973 and 2007. Over the study period, the percentage of younger cancer patients who banked their sperm increased, especially in the 11–14 year age group, rising from 1% in 1986 to 9% in 2006. We found that 4,314 patients attempted to produce a semen sample, 4,004 succeeded, and sperm was banked for 3,616. The mean total sperm count was 61.75 × 106 for the 11–14 year age group, and 138.81 × 106 for the 18–20 year age group. It was noteworthy that intercenter variations in practices involving young patients seeking to preserve their fertility before cancer therapy were observed within this national network.


Our results emphasize the need for decisive changes in public health policy to facilitate the access to reproductive health-care for young cancer patients.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02358-9/fulltext