Birth weight is associated with inner cell mass grade of blastocysts

Blastocysts with a more developed inner cell mass developed into newborns with a greater weight, when corrected for gestational age and gender.

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Authors

Frederick Licciardi, M.D., Caroline McCaffrey, Ph.D., Cheongeun Oh, Ph.D., Cecilia Schmidt-Sarosi, M.D., David McCulloh, Ph.D.

Volume 103, Issue 2, Pages 382-387

Abstract

Objective:

To determine the relationship between blastocyst growth parameters and birth weight.

Design:

Cohort study.

Setting:

University-affiliated fertility center.

Patient(s):

In vitro patients who delivered a singleton after a single-blastocyst transfer.

Intervention(s):

None.

Main Outcome Measure(s):

Birth weight adjusted for gestational age at delivery and gender, with adjusted birth weight examined for association with blastocyst scores and grades.

Result(s):

After standard in vitro fertilization (IVF) and thawed embryo transfers, greater birth weight was associated with a higher inner cell mass grade. The grade of the trophectoderm and stage of the blastocyst did not relate to weight.

Conclusion(s)

Embryonic growth as early as day 5 can predict the progress of fetal development as measured by birth weight.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02299-7/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.