Birth weight is associated with inner cell mass grade of blastocysts

Blastocysts with a more developed inner cell mass developed into newborns with a greater weight, when corrected for gestational age and gender.

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Frederick Licciardi, M.D., Caroline McCaffrey, Ph.D., Cheongeun Oh, Ph.D., Cecilia Schmidt-Sarosi, M.D., David McCulloh, Ph.D.

Volume 103, Issue 2, Pages 382-387



To determine the relationship between blastocyst growth parameters and birth weight.


Cohort study.


University-affiliated fertility center.


In vitro patients who delivered a singleton after a single-blastocyst transfer.



Main Outcome Measure(s):

Birth weight adjusted for gestational age at delivery and gender, with adjusted birth weight examined for association with blastocyst scores and grades.


After standard in vitro fertilization (IVF) and thawed embryo transfers, greater birth weight was associated with a higher inner cell mass grade. The grade of the trophectoderm and stage of the blastocyst did not relate to weight.


Embryonic growth as early as day 5 can predict the progress of fetal development as measured by birth weight.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.